| Saturday, October 26 |
| TIME (ET) | MATCHUP | TV | | | |
| 12:00 PM | Wake Forest at No. 7 Miami (FL) |   | | | |
| 12:00 PM | No. 19 Oklahoma State at Iowa State | | | | |
| 12:00 PM | No. 20 Louisville at South Florida |  | | | |
| 12:00 PM | Connecticut at No. 23 UCF |  | | | |
| 12:00 PM | No. 24 Nebraska at Minnesota |  | | | |
| 12:00 PM | Houston at Rutgers |  | | | |
| 12:00 PM | Ball State at Akron | | | | |
| 12:00 PM | Northwestern at Iowa | BTN | | | |
| 12:21 PM | Vanderbilt at No. 16 Texas A&M | | | | |
| 12:30 PM | Georgia Tech at Virginia | | | | |
| 1:00 PM | Pittsburgh at Navy | CBS Sports Network | | | |
| 1:00 PM | Old Dominion at Norfolk State | | | | |
| 2:00 PM | Miami (OH) at Ohio | | | | |
| 2:30 PM | Toledo at Bowling Green | | | | |
| 3:00 PM | Western Michigan at Massachusetts | | | | |
| 3:00 PM | Temple at Southern Methodist | | | | |
| 3:30 PM | Tennessee at No. 1 Alabama | CBS | | | |
| 3:30 PM | North Carolina State at No. 2 Florida State
Coverage map » |  | | | |
| 3:30 PM | No. 9 Clemson at Maryland | | | | |
| 3:30 PM | No. 10 Texas Tech at No. 15 Oklahoma | FOX | | | |
| 3:30 PM | Duke at No. 14 Virginia Tech | | | | |
| 3:30 PM | Eastern Michigan at No. 18 Northern Illinois | | | | |
| 3:30 PM | Boston College at North Carolina | | | | |
| 3:30 PM | UTEP at Rice | | | | |
| 3:30 PM | Michigan State at Illinois
Coverage map » | | | | |
| 3:30 PM | Buffalo at Kent State | | | | |
| 3:30 PM | Tulsa at Tulane | | | | |
| 3:45 PM | West Virginia at Kansas State | FOX Sports 1 | | | |
| 4:00 PM | Utah at USC | Pac-12 Network | | | |
| 4:00 PM | Troy at Western Kentucky | | | | |
| 5:00 PM | Notre Dame at Air Force | CBS Sports Network | | | |
| 5:00 PM | UAB at UTSA | | | | |
| 6:00 PM | Louisiana Tech at Florida International | | | | |
| 6:05 PM | UNLV at Nevada | | | | |
| 7:00 PM | No. 12 UCLA at No. 3 Oregon | | | | |
| 7:00 PM | No. 21 South Carolina at No. 5 Missouri | | | | |
| 7:00 PM | No. 8 Baylor at Kansas | | | | |
| 7:00 PM | Furman at No. 13 LSU | | | | |
| 7:00 PM | Wyoming at San Jose State | | | | |
| 7:00 PM | South Alabama at Texas State | | | | |
| 7:00 PM | Georgia State at Louisiana-Monroe | | | | |
| 7:00 PM | North Texas at Southern Miss | | | | |
| 7:30 PM | Florida Atlantic at No. 11 Auburn | | | | |
| 7:30 PM | Idaho at Ole Miss | | | | |
| 7:30 PM | Texas at TCU | FOX Sports 1 | | | |
| 8:00 PM | Penn State at No. 4 Ohio State |  | | | |
| 8:00 PM | Arizona at Colorado | Pac-12 Network | | | |
| 8:00 PM | Abilene Christian at New Mexico State | | | | |
| 10:30 PM | No. 6 Stanford at No. 25 Oregon State | | | | |
| 10:30 PM | No. 17 Fresno State at San Diego State | | | | |
| 11:00 PM | California at Washington | FOX Sports 1 | | | |
