2021 NFL schedule release: Picks and predictions for every game

GLENDALE, ARIZONA - AUGUST 20: Quarterback Patrick Mahomes #15 of the Kansas City Chiefs runs up field before the start of the NFL preseason game against the Arizona Cardinals at State Farm Stadium on August 20, 2021 in Glendale, Arizona. The Chiefs defeated the Cardinals 17-10. (Photo by Christian Petersen/Getty Images) /

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KANSAS CITY, MISSOURI – JANUARY 12: Strong safety Tyrann Mathieu #32 of the Kansas City Chiefs reacts during player introductions before the AFC Divisional playoff game against the Houston Texans at Arrowhead Stadium on January 12, 2020 in Kansas City, Missouri. (Photo by Peter G. Aiken/Getty Images) /

Week 11

Thursday Night Football

47. 27. 44. Final. 24

Sunday afternoon

Final. 23. 58. 26. 87

26. 49. 30. 60. Final

14. 50. 24. 53. Final

10. 42. 35. Final. 17

59. 27. 30. Final. 23

42. 22. 52. Final. 27

57. Final. 17. 26. 20

54. Final. 24. 15. 20

27. 46. 31. 16. Final

56. 27. 28. Final. 24

32. 40. 36. Final. 28

123. 34. 124. Final. 21

Sunday Night Football

55. 23. 13. Final. 29

Monday Night Football

28. 48. Final. 24. 31

BYE WEEK: Rams, Broncos

Game of the Week: Colts at Bills

In a rematch of the AFC Wild Card game from a year ago, we get Indianapolis and Buffalo as the weather begins to turn in Western New York.

Despite being a dome team, Indianapolis is built for a physical game. Second-year running back Jonathan Taylor is one of the better youngster in the league and all present a good challenge for Buffalo’s front four. Also, the Colts have a terrific defensive line anchored by tackle DeForest Buckner, arguably the biggest All-Pro and Pro Bowl snub of 2020.

It’ll be fascinating to see if the Colts can stop Josh Allen, though, who lit them up time and against last January. Indianapolis didn’t do much to address the secondary, hoping instead for some more steps forward by men like Khari Willis.

For Buffalo, this is a game that could determine whether it pulls away in the AFC East or has to fight it out with the Miami Dolphins and New England Patriots come December and January.

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