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College basketball Week 16 predictions for every Top 25 game

By Mike Phillips

TUCSON, ARIZONA - FEBRUARY 17: Forward Azuolas Tubelis #10 of the Arizona Wildcats looks for an open teammate at McKale Center on February 17, 2022 in Tucson, Arizona. The Arizona Wildcats won 83-69 against the Oregon State Beavers. (Photo by Rebecca Noble/Getty Images)
TUCSON, ARIZONA - FEBRUARY 17: Forward Azuolas Tubelis #10 of the Arizona Wildcats looks for an open teammate at McKale Center on February 17, 2022 in Tucson, Arizona. The Arizona Wildcats won 83-69 against the Oregon State Beavers. (Photo by Rebecca Noble/Getty Images) /
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Every game counts more with just two weeks left in the college basketball regular season. Here are picks for each Top 25 game in Week 16.

There are only two weeks left in the college basketball regular season and the anticipation for March Madness is beginning to build. The NCAA’s Top 16 seed reveal over the weekend gave us our first glimpse at what a potential bracket could look like and raised the stakes for what could happen in the next seven days.

A few key losses led to some interesting movement in this week’s AP Top 25 poll and a deep lineup of games hints at more shakeups to come. Let’s take a look at every game involving a Top 25 team this week and project the winners of those contests.

Week 16 College Basketball Top 25 Predictions

Note: All games listed below were on the schedule as of post-time. COVID-19 related issues can lead to postponements or cancellations on short notice. Predicted winners are listed in bold.

Monday, Feb. 21

  • Indiana at No. 22 Ohio State – 7:00 p.m. ET – FS1
  • No. 10 Baylor at Oklahoma State – 9:00 p.m. ET – ESPN
  • Arizona State at No. 12 UCLA – 9:00 p.m. ET – FS1

Tuesday, Feb. 22

  • No. 17 Tennessee at Missouri – 7:00 p.m. ET – SEC Network
  • No. 18 Arkansas at Florida – 7:00 p.m. ET – ESPN2
  • Michigan State at No. 25 Iowa – 7:00 p.m. ET – ESPN
  • No. 8 Villanova at No. 21 UCONN – 8:00 p.m. ET – FS1
  • Oklahoma at No. 9 Texas Tech – 8:00 p.m. ET – Big 12 Now/ESPN+
  • Kansas State at No. 5 Kansas – 9:00 p.m. ET – ESPN
  • No. 24 Alabama at Vanderbilt – 9:00 p.m. ET – SEC Network

Wednesday, Feb. 23

  • No. 7 Duke at Virginia – 7:00 p.m. ET – ESPN
  • Xavier at No. 11 Providence – 7:00 p.m. ET – CBS Sports Network
  • TCU at No. 20 Texas – 7:00 p.m. ET – ESPN2
  • No. 14 Houston at Tulane – 8:00 p.m. ET – ESPN+
  • Ole Miss at No. 3 Auburn – 8:30 p.m. ET – SEC Network
  • LSU at No. 6 Kentucky – 9:00 p.m. ET – ESPN
  • No. 13 Wisconsin at Minnesota – 9:00 p.m. ET – Big Ten Network

Thursday, Feb. 24

  • No. 1 Gonzaga at San Francisco – 9:00 p.m. ET – ESPN2
  • No. 22 Ohio State at No. 15 Illinois – 9:00 p.m. ET – FS1
  • Belmont at No. 19 Murray State – 9:00 p.m. ET – ESPNU
  • No. 12 UCLA at Oregon – 9:30 p.m. ET – ESPN
  • No. 23 Saint Mary’s at San Diego – 10:00 p.m. ET – Stadium
  • No. 2 Arizona at Utah – 11:00 p.m. ET – FS1
  • No. 16 USC at Oregon State – 11:00 p.m. ET – ESPN2

Friday, Feb. 25

  • No. 25 Iowa at Nebraska – 9:00 p.m. ET – FS1

Saturday, Feb. 26

  • No. 4 Purdue at Michigan State – 12:00 p.m. ET – ESPN
  • No. 6 Kentucky at No. 18 Arkansas – 2:00 p.m. ET – CBS
  • No. 20 Texas at West Virginia – 2:00 p.m. ET – ESPN or ESPN2
  • No. 3 Auburn at No. 17 Tennessee – 4:00 p.m. ET – ESPN or ESPN2
  • No. 12 UCLA at Oregon State – 4:00 p.m. ET – CBS
  • No. 19 Murray State at Southeast Missouri State – 5:00 p.m. ET – ESPN+
  • No. 7 Duke at Syracuse – 6:00 p.m. ET – ESPN
  • No. 9 Texas Tech at TCU – 6:00 p.m. ET – ESPN2
  • No. 13 Wisconsin at Rutgers – 6:00 p.m. ET – Big Ten Network
  • South Carolina at No. 24 Alabama – 6:00 p.m. ET – SEC Network
  • No. 2 Arizona at Colorado – 8:00 p.m. ET – ESPN2 or ESPNU
  • No. 5 Kansas at No. 10 Baylor – 8:00 p.m. ET – ESPN
  • Creighton at No. 11 Providence – 8:30 p.m. ET – FS1
  • No. 1 Gonzaga at No. 23 Saint Mary’s – 10:00 p.m. ET – ESPN or ESPN2
  • No. 16 USC at Oregon – 10:00 p.m. ET – ESPN or ESPN2

Sunday, Feb. 27

  • No. 21 UCONN at Georgetown – 12:00 p.m. ET – CBS
  • SMU at No. 14 Houston – 12:30 p.m. ET – ESPN
  • No. 15 Illinois at Michigan – 2:00 p.m. ET – CBS
  • No. 22 Ohio State at Maryland – 4:00 p.m. ET – CBS

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