2022 MLB All-Star Game Best Bets, Picks and Predictions (Roundtable)

Los Angeles Dodgers ace Clayton Kershaw.
Los Angeles Dodgers ace Clayton Kershaw. / Ronald Martinez/GettyImages

Who’s ready to make a bet for the Mid-Summer Classic?

BetSided’s Peter Dewey and Ben Heisler each have a play for tonight’s MLB All-Star Game, and they were spot on with their Home Run Derby picks, choosing the two players who made the final in yesterday’s competition. 

First, here are the odds for the 2022 MLB All-Star Game from WynnBET

American League vs. National League Odds, Run Line and Total

Run Line:

  • AL +1.5 (-215)
  • NL -1.5 (+175)


  • AL: -103
  • NL: -107


  • 8 (Over +105/Under -125)

Best Bets for 2022 MLB All-Star Game

AL vs. NL NRFI (-145)

Is it ideal to lay -145 juice in an exhibition game? Not really, but the numbers for both starting pitchers, as well as All-Star Game history indicate that this is a trend worth backing.

Via Shayne Trail, NL starter and Dodgers great Clayton Kershaw is 40-9 in NRFIs since 2020, and has gone 19-3 at home. He's also 5-0 at home this year in not allowing a run in the first.

Shane McClanahan has also been dominant in this spot at 34-10 over his career.

With no runs scored in the first inning of the Mid-Summer Classic since 2016, I'll back another NRFI from two of the best lefties in the game to kick things off. -- Ben Heisler

AL vs. NL UNDER 8 (-125)

One trend that I am intrigued by has to do with the total. The UNDER is 12-3 in the last 15 All-Star Games. I think there are two reasons for this. One, pitchers really are only being asked to go all out for one inning, and hitters are being thrown in for just one or two at bats.

That makes it hard to get any sort of rhythm going at the dish. 

Since 2000, 13 MLB All-Star Games have combined for eight or fewer runs. It seems like a square play, but I’m leaning towards that trend continuing again in 2022. – Peter Dewey