49ers vs. Cowboys Prediction, Odds, Against Spread and Over/Under for NFC Wild Card Round

The Cowboys will host the 49ers in the NFC Wild Card round.
The Cowboys will host the 49ers in the NFC Wild Card round. / Tommy Gilligan-USA TODAY Sports

Sunday afternoon's NFL Wild Card matchup will be a blast from the past when the San Francisco 49ers take on the Dallas Cowboys. The two franchises dominated the NFC back in the 1990's, and now they will face each other for the right to advance to the Divisional Round.

The 49ers snuck into the playoffs by taking down the Rams in overtime in Week 18. The Cowboys also enter the postseason with momentum, after demolishing the Eagles on Saturday night of the final week, beating them by a final score of 51-26.

The last time these two teams faced each other in Week 15 of the 2020 NFL season. Dallas walked away with the 41-33 victory.

Let's take a look at the odds via WynnBET for this NFL Wild Card showdown.

49ers vs. Cowboys Odds, Spread, and Total


  • 49ers +3 (-110)
  • Cowboys -3 (-110)


  • 49ers +130
  • Cowboys -160


  • 50 (Over -110/Under -110)

49ers vs. Cowboys Betting Trends

  • 49ers are 7-2 ATS in their last nine games.
  • The UNDER is 4-1 in the 49ers' last five games.
  • Cowboys are 4-1-1 ATS in their last six games vs. 49ers.
  • Cowboys are 5-1 ATS in their last six games.
  • The UNDER is 8-3 in the Cowboys' last 11 games.
  • Cowboys are 11-1 ATS in their last 12 games vs. NFC opponents.

49ers vs. Cowboys Prediction and Pick

You may not believe it, but the San Francisco 49ers had the top offense in the NFL this season in terms of yards per play, gaining an average of 6.1. The Cowboys are close behind them, ranking third in that statistics averaging 6.0. The big difference between these two teams are their defenses.

The 49ers defense is sixth in opponent yards per play, giving up an average of 5.1, while the Cowboys defense ranks 20th, giving up an average of 5.5. The most important aspect of this game is how effective the San Francisco rushing attack will be against the Dallas defense.

The 49ers run the ball on 47.71% of plays, which is the fourth highest mark in the league. Now they face a Dallas defense that ranks 23rd in opponent yards per carry, giving up an average of 4.5.

The Cowboys roster may be more flashy and sexy, but the playoffs are about being able to play hardnose, ugly football and the 49ers hold a significant advantage in that category. I think San Francisco pulls off the upset in this spot.

Pick: 49ers +130