49ers vs. Jaguars Prediction, Odds, Against Spread and Over/Under for NFL Week 11

The 49ers are a very good team on the road but the Jaguars have been playing much better lately and could give SF a run for its money.
The 49ers are a very good team on the road but the Jaguars have been playing much better lately and could give SF a run for its money. / Trevor Ruszkowski-USA TODAY Sports

The San Francisco 49ers opened as 6-point chalk over the Jacksonville Jaguars in Week 11 ahead of their Week 10 Monday Night Football game against the Rams. The spread has already been bet down to 5 and could be on the move again depending on what happens tonight at Levi’s Stadium. 

Looking ahead to next week, the Niners travel across the country on short rest to take on Jacksonville on Sunday. On the latest "Bet & Breakfast" podcast, our Reed Wallach explained why he's on the Jaguars next week, but will wait to bet the game until the conclusion of Monday Night Football.

The Jaguars are coming off a loss to the Colts last week but have won two of their last four games. Their game against the Bills was a sight to behold and proved to me that there is a lot more talent on this team than their 2-7 record suggests. The Jags had a shot to win last week but rookie QB Trevor Lawrence put the ball on the turf late in the game and pretty much ended his team’s day. 

Here are the odds for this Week 11 matchup, courtesy of WynnBET Sportsbook.

49ers vs. Jaguars, Spread, and Total Odds


  • 49ers: -5.0 (-110)
  • Jaguars: +5.0 (-110)


  • 49ers: -220
  • Jaguars: +185


  • 46.0 (Over -110/Under -110)

49ers vs. Jaguars Betting Trends

  • The 49ers are 3-0 as against the spread (ATS) road favorites this season. 
  • The 49ers are 3-1 ATS on the road this season 
  • The 49ers are 2-1-0 straight-up (SU) in their last three road games. 
  • The Jaguars are 1-3 ATS as a home team. 
  • The Jaguars are 3-3 ATS coming off a loss.
  • The 49ers are 0-1 ATS with a rest disadvantage

49ers vs. Jaguars Prediction and Pick

The 49ers' performance tonight will shed some light on this game a bit more and where the odds will settle at. As of now, the 49ers come off a brutal 31-17 loss to the Cardinals and have won just one game in their last six tries. The Niners have been a much more successful team on the road with a 3-1 record away from Levi’s Stadium but that might not help them as much this week. San Francisco crosses the country on a short week against a team that has begun to find its footing.

The Jaguars are still a below-average team, but I don’t consider them “bad” anymore. They are putting up a fight against every opponent they come up against and the win over the Bills was a revelation. Trevor Lawrence has tons of weapons and he’s finally learning how to use them. I think the Jags have a decent chance to win outright here but I’m going to play it safe on a two-win team and take them on the spread. 

Pick: Jaguars +5.0 (-110) 

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