49ers vs. Packers Prediction, Odds, Against Spread and Over/Under for NFC Divisional Round

Green Bay Packers quarterback Aaron Rodgers.
Green Bay Packers quarterback Aaron Rodgers. / Benny Sieu-USA TODAY Sports

Aaron Rodgers and the Packers have met up with the San Francisco 49ers on more than one occasion.

After the 49ers upset the Cowboys on the road in the Wild Card round, they’ll have another classic matchup on the road in Lambeau Field. Let’s see if there are any trends that we can identity. 

Let’s get started by looking at the odds via WynnBET. 

49ers vs. Packers Odds, Spread and Total


  • 49ers +5.0 (-110)
  • Packers -5.0 (-110)


  • 49ers +190
  • Packers -230


  • Total (Over/Under 47.5)

49ers vs. Packers Betting Trends

  • The 49ers are 5-1 against the spread in their last six games. 
  • The total has gone UNDER in five of the 49ers last six games.
  • The 49ers are 7-3 straight up on the road this season.
  • The Packers are 7-1 against the spread at home this season.
  • The Packers are 12-4 against the spread in their last 16 games.
  • The Packers are 8-0 straight up in the last eight games at home.

49ers vs. Packers Prediction and Pick

In the 2019 NFC Championship game, the Packers traveled to Levi’s Stadium and got positively dominated by the 49ers, 37-20. Despite a solid 31/39 passing line for 326 yards and two touchdowns, Rodgers was picked off twice and their defense couldn’t stop the 49ers rushing attack.

Since that game, the Packers have played the 49ers twice (on the road both times), winning both games by a combined score of 64-45. In their last two meetings, Rodgers has thrown for a total of 533 yards with six touchdowns and zero interceptions. 

I know the 49ers are playing well, and that they’re coming off a road win against the Cowboys as a road dog, but they have major injury concerns to Fred Warner and Nick Bosa. 

The Packers have the 11th-best rush defense, the 10th-best pass defense, and the third-best turnover differential in the NFL this season at +13. They can beat you on the ground, Aaron Rodgers is having yet another MVP-caliber season, and has thrown 37 TDs to only four INTs. 

I’m backing Rodgers and the Packers at home as favorites. The injuries to the 49ers will be worth watching throughout the week in terms of where the line ends, but the best bet right now looks like picking the Packers to make it back to the NFC Championship Game.

Pick: Packers Moneyline (-230)