49ers vs. Rams Betting Guide (How to Bet the NFC Championship)

Los Angeles Rams defensive end Aaron Donald.
Los Angeles Rams defensive end Aaron Donald. / Kirby Lee-USA TODAY Sports

For the third time this season, the Rams and 49ers will play. San Francisco has dominated this matchup this year, winning both games. However, the stakes are much different this time. It's more than just pride or a division title. A trip to the Super Bowl is on the line.

Before you run to place your bet on the NFC Championship game, make sure to take a look at these facts.

49ers vs. Rams Info for Spread Bettors

  • The Rams are currently 3.5-point favorites at WynnBET
  • Los Angeles was 5-4 ATS at home this year.
  • The 49ers are 7-4 ATS on the road this year
  • San Francisco is 3-1ATS as a road underdog
  • Tampa Bay was 6-2 ATS as a home favorite in the regular season
  • The Rams went 2-3 ATS in their last five games
  • The 49ers are 4-1 ATS in their last five games

49ers vs. Rams Info for Moneyline Bettors

  • The 49ers are +152 on the moneyline (bet $100 to win $152)
  • The Buccaneers are -185 on the moneyline (bet $185 to win $100)
  • The 49ers are 4-1 as underdogs this season
  • Los Angeles was 11-5 as a favorite 
  • The Rams are 5-3 as a home favorite

49ers vs. Rams Info for Over/Under Bettors

  • The Over/Under for this game is 46 points (Over -110/Under -110)
  • The UNDER is 3-2 in the Rams’ last five games.
  • The UNDER is 3-1 when the 49ers were road underdogs
  • The OVER was 3-5 when the Rams were home favorites

49ers vs. Rams Info for ALL Bettors

  • The 49ers have already beaten the Rams twice this year.
  • Kyle Shanahan is 2-0 in playoff rematches
  • Sean McVay is 4-0 in playoff rematches
  • The 49ers averaged the most yards per pass (8.1)
  • Los Angeles is second in yards per play (6.0)
  • San Francisco allows the third-fewest yards per play (5.1)


I've picked the Rams to cover several times this week and I'm not going to waver from it now. The Rams offense has put up 30 points in back-to-back games and I don't see the 49ers being able to slow them down this time. If the Rams can get all of their playmakers going (i.e. Odell Beckham Jr. and Cam Akers), it will be a long afternoon for the 49ers.

You can find Donnavan Smoot’s full betting record here.