49ers vs. Rams Prediction, Odds, Against Spread and Over/Under for NFC Championship

San Francisco 49ers tight end George Kittle celebrates in the regular season finale win over the L.A. Rams to make the playoffs.
San Francisco 49ers tight end George Kittle celebrates in the regular season finale win over the L.A. Rams to make the playoffs. / Jayne Kamin-Oncea-USA TODAY Sports

Back in Week 18 of the NFL regular season, the San Francisco 49ers travelled to SoFi Stadium in Los Angeles fighting for their playoff lives.

After trailing 17-0 early into the second quarter, the Niners kept chipping away, eventually pulling off a 27-24 victory in overtime to give them the No. 6 seed in the postseason, and drop the Rams down to the No. 3 seed.

Turns out, it worked out just perfectly for everyone as both teams now face each other for a third time with a spot in the Super Bowl on the line.

Here are the opening odds for the matchup, courtesy of WynnBET Sportsbook.

49ers vs. Rams Odds, Spread and Total


  • 49ers +3.5 (-115)
  • Rams -3.5 (-105)


  • 49ers +155
  • Rams -185


  • 46.5 (OVER -110 | UNDER -110)

49ers vs. Rams Prediction and Pick

The 49ers have had Sean McVay's number both times this season, trouncing them 31-10 back in Week 9 in Santa Clara, and then coming back to win 27-24 in Week 18 in L.A.

Come to think of it, Shanahan's boys have beaten the Rams in six straight games!

Unfortunately for the Niners, that streak ends Sunday.

The Rams have had the kitchen sink thrown at them over the last several weeks; both from the 49ers in their comeback win that was far more important for them than for the Rams, and L.A. nearly becoming the second team to blow a four possession lead in a playoff game to Tom Brady before Matthew Stafford completed the most important throw of his long NFL career to Cooper Kupp downfield.

If you don't think the Rams will have the thought of the 49ers' comeback fresh in their mind after nearly becoming a meme on Sunday afternoon, think again.

There's also the narrative of Matthew Stafford that's evolving before our very eyes. Despite his many years stuck in the mud in Detroit, Stafford's been a comeback king his entire time in the league.

Via NFL Research, Stafford leads all quarterbacks in game-winning drives since 2009; and that includes postseason games, to which he's only played in FIVE his whole 13 year career.

Stafford and the Rams are undefeated when he doesn't throw an interception this season. So far in the postseason, he's 2-0, with 568 passing yards, four touchdowns, and no picks.

The 49ers matched up perfectly against the Packers and got the perfect break when they needed it.

I don't see another big break happening again.

Back the Rams to become just the second ever team to play a Super Bowl in their home stadium for the second consecutive year after never happening in the previous 55 years beforehand.

LEAN: Rams -3.5 (-105)