49ers vs. Rams Prediction, Odds, Against Spread and Over/Under for NFL Week 18

The 49ers and Rams will face-off in NFL Week 18 action.
The 49ers and Rams will face-off in NFL Week 18 action. / Cary Edmondson-USA TODAY Sports
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The Los Angeles Rams will host the San Francisco 49ers in NFL Week 18 action in a matchup between two playoff-bound teams.

The Rams have already locked up their postseason berth, but they can improve their seeding with a win. Meanwhile, the 49ers will need the win in order to guarntee their playoff spot. If they lose, and the Saints beat the Falcons, they'll be on the outside looking in come Wild Card Weekend.

Here are the odds via WynnBET for this NFC West showdown.

49ers vs. Rams Odds, Spread, and Total

Spread:

  • 49ers +5 (-110)
  • Rams -5 (-110)

Moneyline:

  • 49ers +180
  • Rams -220

Total:

  • 44.5 (over -110/Under -110)

49ers vs. Rams Betting Trends

  • 49ers are 6-2 ATS in their last eight games.
  • The UNDER is 4-1 in the 49ers' last five games.
  • The 49ers are 4-1 ATS in their last five games vs. Rams.
  • Rams are 4-1 ATS in their last five games.
  • The UNDER is 12-3 in the Rams' last 15 home games.

49ers vs. Rams Prediction and Pick

Heading into the final week of the regular season in the NFL, you may not guess that the Rams and the 49ers hold the top two offenses in the NFL. It may be surprising, but it's true from a yards per play perspective. They rank first in that category in the league, each averaging 6.1 yards per offensive play.

That's in large part due to their explosive passing schemes. They also rank second and third in yards per pass attempt. The 49ers are averaging 8.5 yards per throw, while the Rams are averaging 8.1.

I expect them to excel in that area in Week 18 as well, as the secondaries for both teams are vulnerable. The Rams defensive strength is stopping the run, but they rank 11th in opponent yards per pass attempt. The 49ers are right behind them, ranking 13th in that stat.

With that all being said, I'm going to take a shot at this being an offensive shootout. Give me the OVER 44.5.

Pick: OVER 44.5