Best Bets to Advance to the Final Four (Who Comes Out of Each Region?)

The 2021-22 NCAA Tournament is upon us with weeks of exciting games to follow. With Selection Sunday behind us, the odds for March Madness are out. WynnBET Sportsbook has compiled an updated rundown of all 68 teams and their odds to win one of the four regions they were slotted into.

As is the case every year, there are a lot of favorites getting attention, along with worthy dark horse candidates.

2022 Men's East Region Winner (Best Finish Non-NJ)

Kentucky +150
Baylor +250
Purdue +400
UCLA +400
Saint Mary's +2000
Texas +2000
North Carolina +2000
Virginia Tech +2000
Indiana +4000
Murray State +5000
Marquette +5000
San Francisco +5000
Wyoming +10000
Akron +10000
Yale +20000
Norfolk State +20000

Baylor may have earned the No. 1 seed in the East but it’s the Kentucky Wildcats that the oddsmakers have pegged as favorites. The Bears are the reigning champions and were the last undefeated team in the nation. But injuries took their toll and left the Bears shorthanded indefinitely. Luckily they have great depth and still have the talent to earn this No. 1 seed.

Another intriguing option is the UCLA Bruins. UCLA had a fantastic run to the Final Four last year and returned all five starters from that team. I think that of all the regions, the East has the biggest chance for the favorites to fail. The Wildcats are the best team but have a very tough path to win the regions.

Lean: UCLA +400

2022 Men's Midwest Region Winner

Kansas +150
Auburn +250
Iowa +400
Wisconsin +1200
LSU +1500
USC +2500
Providence +3000
San Diego State +3000
Creighton +3000
Miami FL +4000
Iowa State +4000
South Dakota State +7500
Richmond +10000
Colgate +10000
Jacksonville State +20000
Texas Southern +25000
Texas A-M CC +25000

Of all the teams on this list aside from Gonzaga, I feel the best about Kansas making it out of the Region on top. This is not only because they are an extremely talented team, but also they got very lucky with the draw here.

The other contenders have red flags that would keep me from getting them. Auburn has slowed noticeably over the last couple of weeks, Providence is a team with no clear leader, and Wisconsin is a team with only one real scoring option. Kansas is well-rounded and has the depth required to make a run at the Final Four.

Pick: Kansas +150

2022 Men's West Region Winner (Best Finish Non-NJ)

Gonzaga -160
Duke +400
Texas Tech +500
Arkansas +1200
Connecticut +1500
Alabama +3000
Michigan State +3000
Memphis +3000
Boise State +5000
Notre Dame +5000
Davidson +10000
New Mexico State +10000
Vermont +10000
Montana State +15000
Cal State Fullerton +20000
Georgia State +20000

Gonzaga is the only team in any region that has non-plus-money odds to win their region. This makes sense as the Bulldogs find themselves as the overall No. 1 seed. Gonzaga has won more games in the NCAA tournament than any other team in the last 10 years. Gonzaga has made the Sweet 16 in six straight tournaments along with two trips to the national championship game during that time. While they haven’t yet come away with a title win, they are a worthy favorite to run through this region.

Pick: Gonzaga -160

2022 Men's South Region Winner (Best Finish Non-NJ)

Arizona +140
Villanova +300
Tennessee +400
Houston +600
Illinois +800
Ohio State +3000
Michigan +3000
Loyola Chicago +4000
TCU +5000
Colorado State +6000
UAB +10000
Chattanooga +15000
Longwood +20000
Delaware +20000
Bryant +25000
Wright State +25000

I tried to stay away from the chalk in these picks but the fact is that these No. 1 seeds feel more dominant than years past. Perhaps no team personifies that more than Arizona in the South Region. I think there is a good chance that Arizona and Villanova meet up in the Elite Eight to decide this Region without much drama in the early rounds. Therefore, this bet comes down to who I think wins that game.

I don’t think Nova can hang with Arizona on the interior and I don’t see any other team having what it takes to knock off the top seed.

Lean: Arizona +140

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