Best MLB Bets for Every Game Today (September 23)

Sep 22, 2022; Los Angeles, California, USA; Los Angeles Dodgers right fielder Mookie Betts (50)
Sep 22, 2022; Los Angeles, California, USA; Los Angeles Dodgers right fielder Mookie Betts (50) / Kirby Lee-USA TODAY Sports
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 With every MLB team back in action tonight, it's only right we have picks for every game today.

There's intense playoff races, strong divisional rivalries and just good ol' fashioned baseball to take us through the night.

Here's a best bet and game odds for every MLB game tonight.

Chicago Cubs vs. Pittsburgh Pirates Prediction and Best Bet

  • Pick: Cubs ML

Milwaukee Brewers vs. Cincinnati Reds Prediction and Best Bet

  • Pick:

Washington Nationals vs. Miami Marlins Prediction and Best Bet

  • Pick: Marlins ML

Atlanta Braves vs. Philadelphia Phillies Prediction and Best Bet 

  • Pick: Braves ML

Boston Red Sox vs. New York Yankees Prediction and Best Bet

  • Pick: OVER 7.5

The Yankees’ offense has exploded in recent games, ranking first in OPS and first in runs scored over the last two weeks. Given Cole’s struggles against Boston and Hill’s struggles this month, I think we see plenty of runs in Game 2 of this series. – Peter Dewey

Houston Astros vs. Baltimore Orioles Prediction and Best Bet

  • Pick: Orioles +1.5 

Toronto Blue Jays vs. Tampa Bay Rays Prediction and Best Bet 

  • Pick: Rays -1.5

Cleveland Guardians vs. Texas Rangers Prediction and Best Bet 

  • Pick: Guardians -1.5 

Los Angeles Angels vs. Minnesota Twins Prediction and Best Bet 

  • Pick: Minnesota +1.5

Detroit Tigers vs. Chicago White Sox Prediction and Best Bet 

  • Pick: OVER 7.5

Giolito gave up four and five runs in starts against the Tigers earlier this season, and he’s been far from elite in the 2022 season with an ERA of 5.07 and Fielding Independent Pitching of 4.16. 

The other aspect that will help an OVER bet is the fact that Chicago crushes lefties, ranking second in baseball in OPS against them in 2022. Rodriguez was solid in his first two starts after returning from the injured list, but he has a 6.04 ERA over his last four outings. Detroit has also lost all four of those games. – Peter Dewey

San Diego Padres vs. Colorado Rockies Prediction and Best Bet 

  • Pick: Rockies +1.5

Seattle Mariners vs. Kansas City Royals Prediction and Best Bet 

  • Pick: Seattle ML

Odds (TBD)

New York Mets vs. Oakland Athletics Prediction and Best Bet 

  • Pick: Mets -1.5

San Francisco Giants vs. Arizona Diamondbacks Prediction and Best Bet 

  • Pick: Arizona +1.5 (-115)

St. Louis Cardinals vs. Los Angeles Angels Prediction and Best Bet 

  • Pick: Cardinals ML

Jose Quintana is something of a reclamation project too this year and he has a 3.16 ERA between his time in St. Louis and the beginning of the year with Pittsburgh. This will be his 30th start and he has been even more reliable than Heaney. Since coming to St. Louis, the Cardinals have only lost once in nine games with Quintana on the mound. He hasn’t surrendered more than two earned runs in a start as a Cardinal either. – Josh Yourish