Bills vs. Ravens Prediction, Odds, Spread and Over/Under for NFL Week 4 (Defense Will Lead Buffalo to Win)

The Buffalo Bills suffered their first loss of the season at the hands of the Miami Dolphins in Week 2. They're still the outright betting favorites to win Super Bowl 57, but they have another tough challenge ahead of them in Week 3 when they head to Baltimore to face the Ravens.

Meanwhile, the Ravens got back on track in Week 3 with a win over the New England Patriots, just a week after blowing a 21-point 4th quarter lead to the Dolphins.

Let's take a look at the odds for this Week 4 showdown, which may just end up being the game of the week.

Bills vs. Ravens Odds, Spread, and Totals

Bills vs. Ravens Betting Trends

• The OVER is 13-7 in the Bills last 20 road games.
• Bills are 0-5 straight up in their last five games in Baltimore.
• The UNDER is 8-2 in the last 10 games between these teams.
• Ravens are 13-6 ATS in last 19 games vs. AFC East opponents.

Bills vs. Ravens Prediction and Pick

This game will feature two MVP frontrunners in Josh Allen and Lamar Jackson, so expect both offenses to explode. But, the Bills have one significant advantage over the Ravens. Their defense.

The Ravens rank 31st in the NFL in opponent yards per play, allowing teams to average 6.5 yards per play against them. Meanwhile, the Bills, for the second year in-a-row, have a top tier defense. They rank second in opponent yards per play at 4.1. That's right, Buffalo's defense is allowing 2.4 fewer yards per play than Baltimore's defense. That's a significant difference.

The Bills are especially good in defending he run, keeping teams to 2.8 yards per carry. Considering the Ravens get 35.58% of their offense on the ground, which is the 9th highest rate in the NFL, Baltimore could struggle to keep up with Buffalo's potent offense.

I'll back the Bills to get back on track with a win and cover.