Bills vs. Titans: Odds, Spread, Over/Under and Prediction for NFL Week 6

The Bills and Titans are set to face-off on Monday Night Football in NFL Week 6 action.
The Bills and Titans are set to face-off on Monday Night Football in NFL Week 6 action. / Christopher Hanewinckel-USA TODAY Sports
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Are the Buffalo Bills the best team in the AFC? People are asking.

After stumbling out of the gates by getting upset by the Steelers in Week 1, the Bills have won four games in a row including a dismantling of Patrick Mahomes and the Kansas City Chiefs on Sunday Night Football in Week 5.

They’ll look to keep the pedal to the metal in Week 6 when they take on the Tennessee Titans, who are coming off a 37-19 win against the Jaguars. The matchup will serve as the Week 6 Monday Night Football game.

The Bills will enter the game with a 4-1 against the spread record this season, while the Titans are at 3-2.

Here are the betting odds for the Week 6 matchup via WynnBET Sportsbook.

Bills vs Titans Spread, Odds, and Total

Spread

Bills -5 (-110)

Titans +5 (-110)

Moneyline

Bills -220

Titans +185

Total

54.5 (Over -110/Under -110)

Bills vs Titans Betting Trends

  • Bills are 13-3 ATS in their last 16 games.
  • Bills are 6-1 ATS in their last seven road games.
  • The OVER is 10-4 in the Titans last 14 games.
  • Titans are 4-12 ATS in their last 16 games against AFC East opponents.
  • Bills vs Titans Prediction and Pick.

The Bills defense had a chance to prove that they were for real in Week 5 when they took on the Chiefs, and they passed with flying colors. Through the first five weeks of the season, the Bills defense ranks first in the NFL in opponent yards per play at 4.3 and opponent points per game at 12.8.

Now they take on a Titans team that ranks 28th in both of those statistics, and have struggled to explode offensively like they had at times last season. The Bills also seem well equipped to slow down Derrick Henry, as they rank fourth in the league in opponent yards per rush attempt at 3.7.

This line could be a trap, but I’ll take the bait and back the Bills without hesitation.

Pick: Bills -5


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