Buccaneers vs. 49ers Prediction and Odds for NFL Week 14 (San Francisco Facing Uphill Battle With Brock Purdy)

Dec 4, 2022; Santa Clara, California, USA; San Francisco 49ers quarterback Brock Purdy (13)
Dec 4, 2022; Santa Clara, California, USA; San Francisco 49ers quarterback Brock Purdy (13) / Sergio Estrada-USA TODAY Sports

The San Francisco 49ers look to keep their three game winning streak alive against the Tampa Bay Buccaneers, but will have to do so with Brock Purdy as their quarterback. 

Tampa Bay escaped Monday Night Football with a win, keeping it in first place in the NFC South. With last second drives and great defense becoming the weekly formula for Tampa Bay, can the Bucs stay close with the 49ers?

Buccaneers vs. 49ers Spread, Odds and Over/Under

Buccaneers vs. 49ers Betting Trends

  • Tampa Bay is 2-3 ATS as the away team
  • The Buccaneers are 2-10 against the OVER
  • San Francisco is 4-1 ATS as a home favorite
  • The OVER is 1-4 when the 49ers are home favorites

Buccaneers vs. 49ers Prediction and Pick

While we saw Brock Purdy step in for the injured Jimmy Garrapollo and lead the 49ers to a win, he’ll go up against one of the best defenses in the NFL this week. Over the last eight games, the Bucs have only allowed more than 23 points once. They are a dominant unit and will be able to truly put Purdy’s abilities to the test. 

Although San Francisco has a great ATS record at home, that was with its first and second-string quarterbacks. The 49ers are going to rely heavily on their running game to keep Purdy comfortable. 

I don’t expect a lot of points in this one, so anything over a field goal is good value to me. We just saw Tom Brady lead the Buccaneers on a last-second win, showing he can still be clutch when needed. 

Each of the Buccaneers’ last five games have been decided by one score. At the very least, Tampa Bay will keep it close – which is what it will do this week. 

You can find Donnavan Smoot’s full betting record here.

Game odds refresh periodically and are subject to change.