Buccaneers vs. Colts Prediction: Tom Brady vs. Matt Ryan Makes for Fun Preseason Finale

Tom Brady is back in action Saturday for the Tampa Bay Buccaneers, as head coach Todd Bowles revealed the team is treating Week 3 of the preseason against the Indianapolis Colts as a dress rehearsal for the regular season. 

However, the Colts are proceeding in the same manner, starting quarterback Matt Ryan in this matchup. 

Who has the edge with both first team offenses getting some run? Here are the odds from WynnBET:

Buccaneers vs. Colts Odds, Spread and Total

Buccaneers vs. Colts Odds, Spread and Total Movement in NFL Preseason Week 3

The Buccaneers have moved from 5.5-point dogs in this game to just 3-point dogs now that Brady and the starters are playing. Since Ryan is also playing, it’s surprising to see oddsmakers favoring the Bucs in such a manner after the original opening line. 

Buccaneers vs. Colts Best Bet and Prediction 

How long Brady and Ryan play in this game remains to be seen, but after they leave the Colts have a key advantage. 

Blaine Gabbert and Kyle Trask have struggled a bit in the preseason, as they led the team to just three points in last week’s loss to the Tennessee Titans. Meanwhile, Colts quarterback Sam Ehlinger threw for 136 yards and two scores last week, completing nine of his 11 pass attempts. 

This is a game that I wouldn't mind hopping in live, especially if the Bucs get out to a hot start. The Colts have better backup quarterback play, which at the end of the day, is more important in the preseason. 

Our guy Josh Yourish was ready to lay the 5.5 with the Colts before this announcement, so I think getting this all the way down at three is a solid value.

Find Peter Dewey’s full betting record here.