Cardinals vs. 49ers Prediction, Odds, Spread and Over/Under for NFL Week 9

The Arizona Cardinals (7-1) lost their first game of the season on Thursday Night Football against the Green Bay Packers in Week 8, 24-21. Kyler Murray threw an interception in the red zone with only 15 seconds remaining, but wide receiver A.J. Green is just as accountable for the turnover, as he didn’t even look for the approaching football.

The Cardinals will look to get back to their winning ways in Week 9 against the San Francisco 49ers at Levi’s Stadium in Santa Clara.

The 49ers (3-4) had their offense operating efficiently against the Chicago Bears last week, moving the ball down the field for 467 total yards of offense. Quarterback Jimmy Garoppolo threw for 322 yards and collected two rushing touchdowns while rookie running back Elijah Mitchell ran for 137 yards and a touchdown. 

San Francisco covered the spread over Chicago, winning by 11 points, 33-22.

Here are the odds for this matchup, courtesy of WynnBET Sportsbook.

Cardinals vs. 49ers Spread, Odds and Total

Spread:

• Cardinals -2.5 (-120)
• 49ers +2.5 (+100)

Moneyline:

• Cardinals -145
• 49ers +125

Total:

• 46.5 (Over -110/Under -110)

Cardinals vs. 49ers Betting Trends

• Arizona is 6-2 against the spread this season.
• San Francisco is 2-5 against the spread this season.
• The 49ers are 0-3 straight up at home this season.
• The Under is 4-0 in the Cardinals last four games as a favorite.
• The Over is 5-0 in San Francisco’s last five games following an ATS win.

Cardinals vs. 49ers Prediction and Pick

Kyler Murray is currently day-to-day with an ankle injury, so how effective the Cardinals offense will be depends on how well Murray can move around on that ankle. 

San Francisco is allowing 127.1 rushing yards per game this season, 26th in the NFL, and could see a heavy dose of the Arizona running back tandem of Chase Edmonds and James Conner. 

The Cardinals defense has done a much better job of keeping the ball out of the endzone, allowing just 17.3 points per game, compared to the 49ers 24.4 points allowed per game. San Francisco’s shaky offense may hit a wall in Week 9 after their impressive showing against the Chicago Bears last week. 

Arizona saw its game against Green Bay end on a costly turnover, but the Cardinals have secured the ball well throughout much of the season, with a turnover differential of plus-5. The same cannot be said of the 49ers offense, which carries a turnover differential of minus-6.

As long as Kyler Murray is good to go on Sunday, I believe that the Cardinals will pick up the road win over San Francisco. I can’t see Arizona losing two in a row, especially against this up-and-down 49ers team.

I’m taking the Cardinals on the spread at -2.5 and on the moneyline at -145.

Pick: Cardinals -2.5 (-110) | Cardinals moneyline (-145)