Cardinals vs. Lions Prediction, Odds, Against Spread and Over/Under for NFL Week 15

The Detroit Lions are going to be in for a long day when the Arizona Cardinals head to town in Week 15.
The Detroit Lions are going to be in for a long day when the Arizona Cardinals head to town in Week 15. / Quinn Harris-USA TODAY Sports

The Detroit Lions finally got their first precious win in Week 13 but were unable to follow up last week. The Denver Broncos pulled away in the second half after outscoring Detroit 21-0 and won 38-10 with little drama. It was a stark reminder that, despite a win, the Lions are still the worst team in the NFL.

To be fair, they did have some bad luck this weekend with De’Andre Swift and Jamaal Williams both missing the game. But I don't think that would have mattered too much in the long run.

As of this writing, the Arizona Cardinals have yet to play their Week 14 game against the Rams on Monday night. The Cardinals are 10-2 and lead the NFC West after back-to-back wins over the Seahawks and Bears in recent weeks.

Here are the odds for this Week 15 NFC showdown. courtesy of WynnBET Sportsbook.

Cardinals vs. Lions, Spread, and Total Odds


  • Cardinals: -14 (-110)
  • Lions: +14 (-110)


  • Cardinals: -900
  • Lions: +600


  • 47.5 (Over -110/Under -110)

Cardinals vs. Lions Betting Trends

  • The Cardinals are 9-3 against the spread (ATS) in their last 13 games. 
  • The Cardinals are 5-3 against teams in the NFC. 
  • The Cardinals are 7-0 ATS in their last seven road games. 
  • The Lions are 8-5 ATS in their last 13 games. 
  • The Lions are 4-2 ATS at home. 
  • The Lions are 4-1 ATS in their last five games. 
  • The Lions are 5-3 ATS against teams in the NFC. 

Cardinals vs. Lions Prediction and Pick

This is a pretty big spread to cover but the Cardinals are one of the best teams in the NFL and the Lions are probably the worst. So, if there were ever going to be a chance to cover 14 it's here.

After the Lions were unable to capitalize on their only win, I think they are about done for the year. They managed to avoid the history books as the first 0-17 team and don’t have anything else to fight for. 

Considering the Cardinals have yet to play, but barring a disaster, I think they are the team to beat in the NFL right now. This leaves the lowly lions little chance at making a game of this. Especially if the injuries to their backfield persist or more players are added to the reserve/COVID-19.

This team just lost by 28 to the Broncos and have no shot against the Cardinals in Week 15. 

Pick: Arizona Cardinals -14 (-110)