Chargers vs. Cardinals Prediction and Odds for NFL Week 12 (Los Angeles Poised to Get Hot)

November 13, 2022; Santa Clara, California, USA; Los Angeles Chargers quarterback Justin Herbert
November 13, 2022; Santa Clara, California, USA; Los Angeles Chargers quarterback Justin Herbert / Kyle Terada-USA TODAY Sports

The Los Angeles Chargers need to start winning games in a hurry to keep their playoff hopes alive. After a Sunday night loss to the Kansas City Chiefs, they're sitting at 5-5 and well outside a current postseason berth.

They have a good chance to bounce back in Week 12 when they take on the Arizona Cardinals, who are lucky to be 4-7 given where they stand in net yards per play.

Let's take a look at the latest odds for this interconference matchup.

Chargers vs. Cardinals Odds, Spread, and Total

Chargers vs. Cardinals Betting Trends

  • Chargers are 5-2 ATS in their last seven games
  • The OVER is 11-5 in the Chargers' last 16 games
  • Chargers are 4-1 SU and ATS in last five games against Cardinals
  • Chargers are 5-0 ATS in their last five road games
  • The OVER is 5-0 in the Cardinals last five games
  • Cardinals are 1-10 straight up in their last 11 home games

Chargers vs. Cardinals Prediction and Pick

I have no interest in betting on the Cardinals, who rank 31st in net yards per play, especially with Kyler Murray's status for the game still up in the air.

The Chargers have disappointed this season, but they've been the most injured team in the league. With players like Keenan Allen starting to get healthy, we could see some positive regression from Los Angeles, and now may be the time to buy low on them.

The Chargers hold in advantage in a key area, third down conversion rate. They rank ninth in the NFL in that stat, while the Cardinals rank 27th. Arizona also ranks 28th in opponent third down conversion rate, and it's been a huge weakness for them this season.

I'm willing to lay the points on the Chargers in Week 12.

You can track Iain's bets on Betstamp here.

Game odds refresh periodically and are subject to change.