Chiefs vs. 49ers Prediction, Odds, Spread and Over/Under for NFL Week 7

Oct 16, 2022; Kansas City, Missouri, USA; Kansas City Chiefs quarterback Patrick Mahomes (15) runs
Oct 16, 2022; Kansas City, Missouri, USA; Kansas City Chiefs quarterback Patrick Mahomes (15) runs / Denny Medley-USA TODAY Sports

Both the Kansas City Chiefs and San Francisco 49ers will look to bounce back in Week 7 of the NFL season after the Chiefs fell to the Buffalo Bills, and the 49ers were upset by the Atlanta Falcons.

The Chiefs are still in first place in the AFC West, but if they want any shot at keeping up with the Bills for the top seed in the conference, they need to get back to their winning ways in a hurry.

Meanwhile, the 49ers are in the middle of a dog fight with both the Rams and Seahawks atop the NFC West, as well three teams sport a 3-3 record.

Let's dive into the odds for this rematch of Super Bowl 54.

Kansas City Chiefs vs. San Francisco 49ers Odds, Spread, and Total

Kansas City Chiefs vs. San Francisco 49ers Betting Trends

  • Chiefs are 1-4 ATS in their last five games
  • The OVER is 10-4 in the Chiefs' last 14 games
  • Chiefs are 5-1 ATS in last six games against 49ers
  • The OVER is 6-1 in the Chiefs last seven road games
  • Chiefs are 14-5-1 in last 20 games against NFC West opponents
  • 49ers are 8-3 ATS in last 11 games
  • 49ers are 6-0 ATS in last six home games

Kansas City Chiefs vs. San Francisco 49ers Prediction and Pick

If you want to attack the 49ers defense, you can do it by protecting the QB, and finding open receivers. Luckily for Chiefs bettors, like myself, that's exactly what Kansas City does well.

The 49ers rank first in opponent yards per carry and sack percentage, so if your offense relies on the running game or it has a bad offensive line, you could be in trouble. The Chiefs, however, rank sixth in QB sacked percentage, while averaging the eighth most yards per pass attempt.

Meanwhile, the 49ers offense relies on setting up the pass with the run, and they may struggle to do that against a Chiefs defense that ranks sixth in opponent yards per carry, allowing just 4.1 yards per rush.

The 49ers offense is going to struggle to keep pace with Patrick Mahomes and company. The Chiefs concert on 50% of their third down opportunities, the second highest rate in the NFL, while the 49ers convert only 40.54% of their third down chances.

Converting third downs is absolutely critical in not only keeping pace with the Chiefs offense, but also in keeping Mahomes off the field.

I think the Chiefs bounce back in a big way on Sunday.

Game odds refresh periodically and are subject to change.

You can track Iain's bets on Betstamp here.