Clemson vs. Louisville Prediction and Odds (A Tale of Two Bad ACC Teams)

The Clemson Tigers and Louisville Cardinals face off today as two of the worst teams in the ACC.
The Clemson Tigers and Louisville Cardinals face off today as two of the worst teams in the ACC. / Dawson Powers-USA TODAY Sports

The Lousiville Cardinals are in the middle of their worst losing streak since 1940. The Cardinals lost 70-63 to Miami on Wednesday which brings their current streak to seven games. After losing by 12 at the half, Louisville was able to pull the game back within three but was unable to finish the job. As bad as that is, things aren’t going all that much better for the Clemson Tigers who are coming off their fifth straight loss.

The Tigers fell to the Florida State Seminoles 81-80 in what can only be described as a heartbreaking conference loss. With nothing left to play for other than to avoid embarrassment, it’s hard to know what to expect from this game. Here are the odds for this ACC showdown, courtesy of WynnBET Sportsbook.

Clemson vs. Louisville Odds, Spread, and Total


  • Clemson -6.5 (-110)
  • Louisville +6.5 (-110)


  • Clemson -160
  • Louisville +125

Total: 154 (Over -110/Under -110)

Clemson vs. Louisville Prediction and Pick

For as bad as Louisville has been this year in the win/loss column, they managed to be significantly worse against the spread. Heading into tonight, Louisville is 1-6 ATS in their last seven games and 2-13 in their last 15 games. As home underdogs, they are 0-3 ATS and 3-11 in all home games this season. The Cardinals haven’t covered a game at home since Dec. 14 and I am not confident that they can turn it around tonight against Clemson. 

Now, this is not to say that Clemson isn’t without its issues. They haven’t covered in any of their last five games and are 5-6-2 ATS following a loss. But, overall, they are 12-11-3 ATS on the year and 3-5-1 ATS as a road team. 

Comparatively speaking, Clemson has a superior offense that ranks 120th in the nation compared with the Cardinals' rank of 228th. The Cardinals rebound well on offense but that is about all they do effectively on that side of the ball. They can’t shoot free throws (274th in the nation), from downtown (283rd), or in the second half when it counts (280th). All good reasons to fade the Cardinals as the worse of two bad teams. Clemson is pretty bad too so I’m going to stay away from the spread and sacrifice some value to take the Tigers on the moneyline.

Lean: Clemson -160 to win

Follow all of Matt De Saro’s betting picks HERE