Clemson vs. Notre Dame Prediction and Odds for College Football Week 10 (Tigers too Physical for Irish)

Oct 22, 2022; Clemson, SC, USA; Clemson running back Will Shipley (1) runs for a 50-yard touchdown
Oct 22, 2022; Clemson, SC, USA; Clemson running back Will Shipley (1) runs for a 50-yard touchdown / Anderson Independent Mail-USA TODAY

Notre Dame's volatile season continued last weekend with the Irish improving their record 5-3 with a win at Syracuse last weekend. Now, they play host to a College Football Playoff hopeful in Clemson.

The Tigers appeared inside the top four in the first College Football Playoff ranking on Tuesday, Clemson will need to hold serve as a small road favorite in South Bend, Indiana in order to fortify their standing as a top four team.

How will it go down on Saturday night? Here are the odds for this Week 10 matchup:

Clemson vs. Notre Dame Odds, Spread and Total

Clemson vs. Notre Dame Betting Trends

  • Notre Dame is 3-0 against the spread (ATS) as an underdog this season
  • Notre Dame is 1-4 ATS at home
  • Clemson is 3-1 ATS on the road this season
  • Notre Dame has gone OVER in two of three games
  • Clemson has covered in three of their last four games

Clemson vs. Notre Dame Prediction and Pick

I think this is a poor matchup for a limited Notre Dame offense. The Irish hung 41 points on the road last week, but needed a pick six and a blocked kick to set up a short touchdown drive to do it. Overall, the Irish averaged less than five yards per play.

Notre Dame's offense continues to struggle under Drew Pyne, who completed nine of his 19 passes in the win at Syracuse and will be facing an elite unit in Clemson, who is 24th in the country in yards per play allowed and success rate. The Tigers are also 10th in the country in terms of yards per carry, allowing less than three per touch, meaning that Pyne is going to have to pass to keep his team in the game.

The last time we saw Clemson ahead of their BYE week, quarterback D.J. Uiagalelei was benched in the second half against Syracuse for top recruit Cade Klubnik. With a bye week to prepare, I expect we see the veteran back under center, but his job may not be as difficult considering Notre Dame is outside the top 100 in stopping the run (defensive rush success rate).

Clemson was plagued by turnovers, including three inside Syracuse territory, but the Tigers were able to move the ball at will against the Orange. Without flukey turnovers, that score isn't as close, and I think we see another double digit win for Clemson as they march towards the College Football Playoff.

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Game odds refresh periodically and are subject to change.