College Football Upset Picks for Week 2 (Louisville, Houston Strong Road Underdogs)

Dec 28, 2021; Birmingham, Alabama, USA; Houston Cougars quarterback Clayton Tune (3) looks to pass
Dec 28, 2021; Birmingham, Alabama, USA; Houston Cougars quarterback Clayton Tune (3) looks to pass / Marvin Gentry-USA TODAY Sports

College football is one of the most volatile sports you can bet on.

Trying to find an underdog on Saturday's is as thrilling as it gets as there is always chaos on fall Saturday's when watching the college kids play. Last week we saw Old Dominion topple their in-state foe Virginia Tech the biggest upset on the card. What else is in store for Saturday?

Here are two live underdogs that can go on the road and get a win this weekend:

Louisville (+188) vs. UCF

Early Reed guest Tom Casale shared on the show this was his favorite underdog pick of the weekend, noting that this was too many points to give either team. With a pair of dynamic quarterbacks in Malik Cunningham of Louisville and John Rhys Plumlee of UCF, this could be a game that is decided on the final possession.

With that in mind, Casale is interesting in taking Louisville to pull the upset in a game that he sees as more of a coin flip, despite Louisville's poor showing last weekend in Syracuse (31-7 loss).

Hear the whole handicap for yourself from our most recent episode of The Early Reed:

Houston (+146) vs. Texas Tech

I am bullish on Houston heading into the season, and will not change my opinion despite the poor offensive showing for the first three quarters of the UTSA game. Tune and his No. 1 receiver Tank Dell were able to navigate the Roadrunners defense, connecting for two touchdowns and a two-point conversion.

It's worth noting that Texas Tech let up several explosive plays to FCS foe Murray State in Week 1. While it didn't effect the final score (the Red Raiders rolled to a 63-10 win), it will matter here against Tune and this Houston passing game.

Meanwhile, the Red Raiders were able to bring in Zach Kittley from Western Kentucky, who helped build one of the strongest offenses in the country last season. He showed that he may be more than Bailey Zappe's play caller in Week 1, hanging 63 on Murray State. Despite losing quarterback Tyler Shough to injury, backup Donovan Smith has experience last season and this game should be tight throughout.

Smith showed his capable, but now that this number has drifted out to +4 and nearly +150 on the moneyline, I think there's enough variance to take a shot on Houston. Both offenses will score, and similar to how Tom sees the Louisville-UCF game going, I think this could be a last team with the ball wins type of matchup.

In that case, give me the underdog who has a talented quarterback and the best receiver on the field.

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