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Colts vs. Cardinals Prediction, Odds, Against Spread and Over/Under for NFL Week 16

By Matt De Saro

The Arizona Cardinals are in trouble and the Colts present a tough matchup in Week 16.
The Arizona Cardinals are in trouble and the Colts present a tough matchup in Week 16. / Grace Hollars/IndyStar / USA TODAY
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NFL fans are getting a great present on Christmas Day evening when the Indianapolis Colts head to State Farm Stadium to take on the Arizona Cardinals. 

The Cardinals are coming off one of the worst upset losses of the season, getting beat down by the tragically bad Detroit Lions as 13.5-point favorites. It was their second straight loss and leaves them with a 10-4 record as they cling on to their lead in the NFC West.

On the flip side, the Colts have are nice two-game win streak going and have won five of their last six. Once again, the team was led to victory by Jonathan Taylor who leads the league in rushing yards and touchdowns. He will be tested by a good Cardinals defense that needs a redemption game after the Lions debacle. 

Here are the odds for this Week 16 showdown, courtesy of WynnBET Sportsbook.

Colts vs. Cardinals, Spread, and Total Odds

Spread:

  • Colts: +1.5 (-110)
  • Cardinals: -1.5 (-110)

Moneyline:

  • Colts: +105
  • Cardinals: -125

Total:

  • 49 (Over -110/Under -110)

Colts vs. Cardinals Betting Trends

  • The Colts are 8-3 against the spread (ATS) in their last 12 games. 
  • The Colts are 4-2 straight up (SU) in their last six games against the Cardinals.  
  • The Colts are 5-0 ATS in their last five road games. 
  • The OVER is 5-1 in the Colts' last six games against the NFC. 
  • The Cardinals are 8-4 ATS in their last 12 games. 
  • The Cardinals are 3-8 ATS in their last 11 home games. 
  • The Cardinals are 5-0 ATS in their last five games against the AFC South. 

Colts vs. Cardinals Prediction and Pick

Despite the Cardinals’ strong defense, Jonathan Taylor has proven that he can run on just about any team. He doesn’t lead the NFL in rushing by accident. I know many are calling for the Cardinals to rebound and get a much-needed win here, but I am not so quick to dismiss the Colts. The Cardinals are just 3-8 ATS at State Farm Stadium which means they are still being overvalued at home. As a home favorite, they have covered just twice in six tries. 

The loss of DeAndre Hopkins has left Kyler Murray without his No. 1 wideout and it showed last week. I think they continue to struggle, fail to contain Taylor, and get upset for the third straight week. 

Pick: Indianapolis Colts +105 to win

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