Colts vs. Titans: Odds, Spread, Over/Under and Prediction for NFL Week 3

Derrick Henry is going to run wild against a banged up Colts team.
Derrick Henry is going to run wild against a banged up Colts team. / Joe Nicholson-USA TODAY Sports

The Indianapolis Colts, who had a host of injuries heading into the season, suffered yet another late in Sunday’s loss to the Los Angeles Rams. Aaron Donald sacked Carson Wentz in the fourth quarter, and Wentz sprained his ankle in the process. 

Wentz’s status ahead of Sunday’s matchup against the Tennessee Titans on the road is unknown, but in a critical matchup between two AFC South teams, no Wentz could lead to a nightmare 0-3 start. 

Here are the odds for Sunday’s tilt that could go a long way in deciphering the division, courtesy of WynnBET Sportsbook.

Colts vs. Titans Spread, Odds and Over/Under


Titans: -5 (-115)

Colts: +5 (-105)


Titans: -255

Colts: -205

Total: 48 (Over -110/Under -110)

Colts vs. Titans Betting Trends

  • Indianapolis is 10-8-1 ATS against AFC South opponents since Frank Reich became head coach in 2018. 
  • Tennessee is 9-9 ATS against AFC South opponents since Mike Vrabel became head coach in 2018. 
  • Tennessee is 11-7 to the OVER against division opponents under Vrabel 
  • The Titans are 19-11-1 to the OVER after a win, the best mark in the NFL under Vrabel.

Colts vs. Titans Prediction and Pick

The crux of this handicap comes down to who is at quarterback for the Colts, and the early reports on Wentz's injury is not promising, as he's dealing with sprains to both ankles.

If the quarterback can’t play on Sunday, it’s going to be Jacob Eason under center. Eason had a tall order on Sunday, coming in with under two minutes left against one of the best defenses in the league, the Rams. He threw a game sealing interception on his second pass attempt. 

Whether it’s a hobbled Wentz or the outmatched Eason, the Colts offense is not suited to match the Titans firepower that had a come from behind win on the road against the Seahawks on Sunday.

Tennessee's offense found their rhythm after struggling against the Cardinals. Derrick Henry rushed for 160 yards and Julio Jones had a breakout performance for his new team, hauling in six catches for 128 yards. Now the Titans will face a hobbled Colts defense.

Indianapolis has battled the injury bug all season, without cornerback Xavier Rhodes on Sunday. In addition the team was down tackle Braden Smith and receiver T.Y. Hilton.

The Colts offense lacks explosiveness with just three pass plays for more than 20 yards through two games. Not to mention, Wentz has been sacked six times already. If he is playing and hobbled, Indy can be playing form behind the sticks. If it’s Eason, I don’t have faith he can attack the Titans defense. 

Against a Colts defense that hasn’t had their starting corner Rhodes, I’m expecting the Titans offense to rip off more chunk plays through both the air and the ground. 

I'm not rushing to back an injured Wentz or Eason, and will jump on Titans -5 as it sits in a dead zone from a spread perspective. If Wentz does go, I still see the Titans as 4.5 point favorites; if it’s Eason, I’d play Tennessee at anything under a touchdown so I’m willing to get involved now. 

Pick: Titans -5

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