Florida State vs. Louisville Prediction, Odds, Spread and Over/Under for College Football Week 3

Louisville plays on Friday night for the second straight week, can they make it back-to-back Friday victories?

After a concerning performance on the road in Week 1, losing to Syracuse 31-7, Malik Cunningham and the Cardinals responded by winning at UCF, 20-14. The Cardinals now come home for the first time this season, hosting Florida State in an ACC showdown.

The Seminoles got off to a hot start this season, bludgeoning Duquesne before knocking off LSU on a neutral field. After an early bye week, the Noles hit the road to try to make it a 3-0 start.

How should we handle this one with FSU entering as a road favorite? Let's first check out the odds from FanDuel Sportsbook:

Florida State vs. Louisville Odds, Spread and Total

Florida State vs. Louisville Betting Trends

• Florida State has never been a road favorite under Mike Norvell
• However, since 2013, the Seminoles are 5-6 against the spread (ATS) as road favorites
• Prior to this season, home underdogs of a field goal or less in conference play are 123-100-8 ATS

Florida State vs. Louisville Prediction and Pick

This is an interesting situation for the Noles, who won outright as four-point underdogs to LSU, and are now favored against a mercurial Louisville, who has had two very different outcomes in their first two games.

The Cards go as Cunningham goes, and it's been a tale of two games for him. Cunningham passed for 152 yards and threw two picks while only rushing for 34 yards in the loss at Syracuse, but then combined for 322 yards and a rushing touchdown in the win at UCF. What will we see from him in the home opener?

Florida State's defense should have the edge in the trenches similar to how they gave Jayden Daniels fits in the LSU game, and they also had an extra week to prepare for this one. Louisville's offensive line has been concerning this season, ranking 90th in offensive line yards, so Cunningham may be on the run often.

On the other side, Travis looked in control of the LSU game from the jump and I'm bullish on his ability to carry the Noles back to bowl eligibility with a full season under center. Norvell has had his team playing up tempo through the first two games, but I think this game may be more of a defensive struggle.

Travis is a superior passer than John Rhys Plumlee of UCF, but is dual threat quarterback who likes to use his legs. Louisville was above average in defending both explosive runs and passes and think they can limit chunk plays against the Seminoles.

These two met in Tallahassee last year, a 31-23 road victory for the Cards (Travis didn't start) and the total was 60.5. I'm going to lean towards the under in this one as I think we see both defenses limit big plays and this one is played tight until the end.