Guardians vs. White Sox Prediction and Odds for Wednesday, May 11 (Cleveland has a Problem on the Mound)

Chicago White Sox v Boston Red Sox
Chicago White Sox v Boston Red Sox / Winslow Townson/GettyImages

This is one of the more interesting series this week as the Chicago White Sox and Cleveland Guardians are both looking for their way in an underperforming AL Central. The White Sox were expected to run away with the division but haven’t been able to get out of their own way and are currently third. Similarly, the Guardians were expected to challenge the White Sox but went 8-12 in their first 20 games. 

But, after a recent bump in their quality of play, both teams are back around .500 and streaking towards the top of the division. 

The White Sox won six in a row before losing in Game 1 to the Guardians, while Cleveland moved to 2-8 in their previous ten games with the win. That game was a wild one that ended 12-9 in the 11th inning. 

Here are the odds for this game, courtesy of WynnBET Sportsbook

Guardians vs. White Sox Odds, Run Line, and Total

Run Line

  • Guardians: +1.5 (-195)
  • White Sox: -1.5 (+165)


  • Guardians: +124
  • White Sox: -134

Total: 8.5 (Over -110/Under -110)

Guardians vs. White Sox Prediction and Pick

While both teams have had similar runs over the last couple of weeks, I think the White Sox are the clear choice on Wednesday to take Game 3 of this series, and it all has to do with Aaron Civale.

There are some guys whose names pop up on the rotation each week that I can’t believe are still getting started. Civale is one of those guys. In his five previous starts, Civale has managed to amass an ERA of 9.45 and a whip of 1.70. What makes me question the Guardians' choice to trot him out again boils down to the fact that he is clearly regressing.

Civale looked decent in his first two starts despite an ERA of 6.14. But things went way off the rails and he’s given up 16 earned runs in his last 12 ⅔ innings. He’s still striking out a lot of batters but has been unable to limit runs despite averaging around just one walk per game. 

The White Sox scored more than four runs for the first time since May 1 on Monday and I think their bats stay hot against Civale here. 

Pick: White Sox ML 

Follow all of Matt De Saro’s betting picks HERE