Indiana vs. Ohio State Prediction and Odds for College Football Week 11 (C.J. Stroud Boosts Heisman Campaign)

Ohio State survived a wind-filled game against Northwestern last week and now returns home to face another bottom of the barrel Big Ten foe in Indiana.

C.J. Stroud has become the Heisman Trophy favorite despite rushing for more yards than passing last week as he is the leader of the No. 2 Buckeyes, can he get back on track against a listless Indiana secondary? Let's see if he can bolster his Heisman standing with a big afternoon in Columbus:

Indiana vs. Ohio State Odds, Spread and Total

Indiana vs. Ohio State Betting Trends

• Ohio State is 4-4-1 against the spread (ATS) this season
• Indiana is 3-6 ATS this season
• Ohio State has gone OVER in four of six games this season

Indiana vs. Ohio State Prediction and Pick

With a spread this big, the question is will the Buckeyes' starters stay on the field long enough to cover this near six touchdown spread? I'm not certain, but I do think Ryan Day and the offensive staff want to bolster Stroud's stats with a big outing against an Indiana defense that is 116th in EPA/Pass this season.

Stroud is fresh off a game where he rushed for 79 yards and passed for 76 as the team played in winds north of 40 miles per hour against Northwestern. Back at home against a poor opponent, I expect Stroud to get his numbers and move to the odds on favorite to win the Heisman Trophy.

Give me that Buckeyes team total over.

PICK: Ohio State Team Total OVER 48.5

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Game odds refresh periodically and are subject to change.