Louisville vs. Clemson Prediction and Odds for College Football Week 11 (Tigers Ripe for a Home Upset by Cardinals)

Louisville QB, Malik Cunningham
Louisville QB, Malik Cunningham / Scott Utterback/Courier Journal / USA

The Clemson Tigers finally got exposed against the Notre Dame Fighting Irish in Week 10, getting smoked on the road in South Bend 35-14.

Now the Tigers are No. 10 in the latest College Football Playoff rankings, and could fall even further if their offensive issues aren’t figured out.

Meanwhile, the Louisville Cardinals have shaken off their rough start to the season and seems to have it rolling down the stretch. The Cardinals are 6-3 after a 34-10 beatdown of James Madison last week. 

The 8-1 Tigers are eliminated from playoff contention, but look to stay atop the ACC at home this week. Let’s see if Vegas thinks that they’ll do it. 

Louisville vs. Clemson Odds, Spread and Total

Clemson and Louisville Betting Trends

  • Louisville is 6-3 ATS
  • Clemson is 4-5 ATS
  • Louisville is 4-0 ATS in their last four
  • Over is 4-1 in Louisville’s last five conference games
  • Clemson is 5-0 ATS in last five meetings

Louisville vs. Clemson Prediction and Pick

Clemson has not been as good as their overall ranking would tell you. Their offense has been horrible since Trevor Lawrence left for the NFL and need to make the switch to backup quarterback and stud recruit Cade Klubnik. So far, head coach Dabo Swinney has been stubborn to this point and continues to play D.J. Uiagalelei. As a result, Clemson ranks just 63rd in total offense and against Notre Dame, Uiagalelei went 27-for-39 for 191 yards with a touchdown and an interception in their blowout loss.

Louisville is not far off from Clemson. They started the season 2-3, but haven’t lost since and quarterback Malik Cunningham is playing really great football. Louisville ranks 45th in total offense, but over their four-game winning streak they are averaging 35 points per game. Last week vs. JMU, Cunningham threw for 223 yards and three touchdowns.

Clemson's loss last week exposed them as the frauds they are, and I don’t expect that will be their last loss of the year. Louisville is rolling and I love the momentum they come in with.

It might be scary, but give me the Cardinals on the moneyline. 

Pick: Louisville +235

Follow all Josh Yourish’s bets HERE

Game odds refresh periodically and are subject to change