Louisville vs. UCF Prediction, Odds, Spread and Over/Under for College Football Week 2

Sep 1, 2022; Orlando, Florida, USA; UCF Knights quarterback John Rhys Plumlee (10) throws a pass
Sep 1, 2022; Orlando, Florida, USA; UCF Knights quarterback John Rhys Plumlee (10) throws a pass / Mike Watters-USA TODAY Sports

It was two very different Week 1's for UCF and Louisville.

UCF was able to handle South Carolina State 56-10 while Louisville got smoked by Syracuse 31-7 in the Carrier Dome, one of the more surprising results of Week 1. The Cardinals closed as five point favorites in that one and now enter this matchup as underdogs in a rematch of the thrilling matchup in 2021.

Louisville won that one in dramatic fashion, taking back an interception in the final seconds to take out UCF. Can we expect more chaos on Friday night in the Bounce House with a pair of dual threat quarterbacks?

Louisville vs. UCF Odds, Spread and Total


  • Louisville: +6.5
  • UCF: -6.5


  • Louisville: +195
  • UCF: -235


  • 61.5 (Over -110/Under -110)

Louisville vs. UCF Betting Trends

  • UCF is 49-13 straight up (SU) at home since 2012
  • UCF is 26-18 against the spread (ATS) since 2012 against non conference competition
  • Louisville is 3-6-1 ATS as a road underdog under Scott Satterfield

Louisville vs. UCF Prediction and Pick

Louisville couldn't get things going on Saturday night against Syracuse, scoring just 1.75 points per opportunity in the four times they cross the Orange 40 yard line. However, if you dig deeper, the Cardinals did move the ball pretty well, averaging 6.2 yards per play compared to Syracuse's 6.8 YPP.

The Cardinals didn't pick up two fourth downs and the team lost the turnover battle 3-0. Those things add up on the road and it won't get much easier as the team travels to the Bounce House to play UCF, who looks more dynamic at quarterback with John Rhys Plumlee at the helm.

The Ole Miss transfer is a dual threat quarterback who is flanked by an elite running back in Isaiah Bowser. The Golden Knights also have a host of talent on the defensive line that is familiar with dual threat quarterbacks and were fantastic against the run last season, allowing less five yards per carry. Can they contain Malik Cunningham?

This line has shot up after Louisville's lackluster performance in Western New York, too far for me to play it, but I do think UCF has the ability to outscore the Cardinals in what should be a high scoring affair.

Louisville's defense couldn't slow down the rug game, the Orange average oved five yards per carry and completed 73% of their passes, and I expect Plumlee to run wild at home. With both offenses capable of big outings, I'll lean towards the over and key in on UCF as a moneyline parlay piece into Saturday.


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