Mets vs. Giants Prediction and Odds for Wednesday, May 25 (New York Has San Francisco's Number)

New York Mets star Pete Alonso.
New York Mets star Pete Alonso. / Thearon W. Henderson/GettyImages

The New York Mets and San Francisco Giants finish up their three-game midweek series on Wednesday at Oracle Park. The Mets entered this series as underdogs but crushed San Francisco in Game 1 on Monday 13-3. It was just more of the same from the Mets who continue to dominate the rest of the league even when getting underdog odds. The Mets are running away with the NL East with a nearly double-digit lead over the rest of the field. New York already beat the Giants in three of four games in their last series. 

The Giants, on the other hand, are struggling to remain above .500 and are in third place in the NL West behind the Dodgers and Padres. LA and SD are in a dead heat atop the division while the Giants are in danger of falling off the pace. I don’t think this series with the Mets will end up being very kind to them as they fall deeper into the bottom tier of the division. 

Here are the odds for this game, courtesy of WynnBET Sportsbook

Mets vs. Giants Odds, Run Line, and Total

Run Line

  • Mets: +1.5 (-190)
  • Giants: -1.5 (+155)


  • Mets: +112
  • Giants: -122


  • 8.5: (Over -125/Under +105)

Mets vs. Giants Prediction and Pick

The Mets have beaten up the Giants multiple times this year. Yet, the Giants keep opening as betting favorites. I wonder how many wins they need to earn over the Giants before the bookmakers finally catch up. In the meantime, I loved getting New York +130 for their 13-3 blowout win.

Via, the Mets announced their starter today will be left-hander Thomas Szapucki as he gets the call up from AAA.

If that is the case, I still can’t see a world where betting against the Mets makes a lot of sense. They are cruising on both sides of the ball and the Giants lost four straight heading into this series including Game 1 on Monday. In the two most recent of those losses, the Giants were outscored 23-4 by the Padres and Mets. 

I picked the Mets as my underdog of the day on Monday, and Tuesday, and will back them again today as a far superior team overall. I’m not too worried about their starting pitcher, whoever it may be. Their entire staff has been electric this year and should do enough to give the offense a chance to win. 

Pick: Mets ML +112

Follow all of Matt De Saro’s betting picks HERE