Monday Night Football Best Prop Bets for 49ers vs. Cardinals (Trust DeAndre Hopkins, Brandon Aiyuk)
By Peter Dewey
There are some questions in Week 11 on Monday Night Football, as the Arizona Cardinals may not have quarterback Kyler Murray (hamstring, questionable) for the second straight week when they take on the San Francisco 49ers.
With that in mind, how should bettors attack the prop market?
Here are three plays I’m considering for this NFC West showdown:
Best NFL Prop Bets for 49ers vs. Cardinals
- DeAndre Hopkins Anytime Touchdown Scorer
- Christian McCaffrey OVER 101.5 Rushing and Receiving Yards
- Brandon Aiyuk OVER 55.5 Receiving Yards
DeAndre Hopkins Anytime Touchdown Scorer
DeAndre Hopkins has been a target hog since returning to the Cardinals’ lineup, receiving 13-plus targets in three of his four games.
Even if Colt McCoy gets the start in this game, I think Hopkins goes off, especially since he made 10 grabs for 98 yards with McCoy under center last week.
Hopkins has two scores on the season, and the Cardinals are going to involve him heavily, especially with Hollywood Brown out once again.
Christian McCaffrey OVER 101.5 Rushing and Receiving Yards
Christian McCaffrey has been a beast since joining the 49ers, scoring three touchdowns in three games and posting a game with over 150 total rushing and receiving yards in his second contest with the team .
I think CMC’s role is going to expand with each week under Kyle Shanahan, and he saw 20 opportunities (carries and targets) last week.
If he sees similar usage in Week 11, he should be able to clear this prop with ease.
Brandon Aiyuk OVER 55.5 Receiving Yards
Brandon Aiyuk has been terrific as of late for the 49ers, clearing this total in five straight games and posting four games in a row with over 80 receiving yards.
Even though Deebo Samuel gets the most attention of the 49ers’ pass catchers, Aiyuk has six or more targets in each of his last four games.
55.5 is just too low of a number for Aiyuk given his recent play.
Find Peter Dewey’s full betting record here.
Game odds refresh periodically and are subject to change.