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NFL Picks Against the Spread for Every Team in Week 10

By Iain MacMillan

Oct 30, 2022; Inglewood, California, USA; San Francisco 49ers running back Christian McCaffrey (23)
Oct 30, 2022; Inglewood, California, USA; San Francisco 49ers running back Christian McCaffrey (23) / Gary A. Vasquez-USA TODAY Sports
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Week 10 of the NFL season is here, and no matter how your bets have gone this year, you have time to make it up. Let's all have a strong second half to the season, starting with this week's slate.

In this article, I'll be giving you my spread pick for all 14 NFL Week 10 games. If you only care about the moneyline and which team will win, check out my straight-up picks article here.

Also, if you want my best bet for each game including spreads and totals, check out this week's episode of the Bacon Bets Podcast.

Here are my best spread bets for all NFL Week 10 games.

NFL Week 10 Spread Bets

Atlanta Falcons vs. Seattle Seahawks

  • Pick: Falcons -2.5

Seattle Seahawks vs. Tampa Bay Buccaneers

  • Pick: Seahawks +3

Minnesota Vikings vs. Buffalo Bills

  • Pick: Bills -3.5

Detroit Lions vs. Chicago Bears

  • Pick: Lions +3

Jacksonville Jaguars vs. Kansas City Chiefs

  • Pick: Jaguars +9.5

The Jaguars are too good of a team to be this big of underdogs against the Chiefs. Sure, they're 3-6, but they rank inside the top half of the NFL in almost every category, including 11th in net yards per play. The Chiefs should win, but covering this spread is another story.

Cleveland Browns vs. Miami Dolphins

  • Pick: Dolphins -3.5

Houston Texans vs. New York Giants

  • Pick: Texans +5.5

No team that ranks in the bottom five of the NFL in net yards per play should big bigger than a field goal favorite against anyone. The Giants are 29th in net yards per play and in the bottom five in just about every category you want to look at. Don't be fooled by their 6-2 record, the Giants may struggle in this game.

New Orleans Saints vs. Pittsburgh Steelers

  • Pick: Saints -1.5

Denver Broncos vs. Tennessee Titans

  • Pick: Titans -2

Indianapolis Colts vs. Las Vegas Raiderrs

  • Pick: Raiders -5.5

Dallas Cowboys vs. Green Bay Packers

  • Pick: Cowboys -4.5

It's time to accept that the Green Bay Packers aren't a good football team. They struggled all game against the worst defense in the league last week, and now they have to face one of the best defenses in the Cowboys.

Arizona Cardinals vs. Los Angeles Rams

  • Picks: Rams -1.5

Los Angeles Chargers vs. San Francisco 49ers

  • Pick: 49ers -7

Washington Commanders vs. Philadelphia Eagles

  • Pick: Commanders +10.5

A hole has been exposed in the undefeated Eagles. They rank 29th in opponent yards per carry. If you allow the other team to run the ball successfully against you, it's going to be tough to cover a double-digit spread.

You can track Iain's bets on Betstamp here.

Game odds refresh periodically and are subject to change.

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