NFL Straight Up Picks for Every Team in Week 16 (Back Patriots and Saints as Underdogs)

Dec 5, 2022; Tampa, Florida, USA;  New Orleans Saints cornerback Bradley Roby (21) runs with the
Dec 5, 2022; Tampa, Florida, USA; New Orleans Saints cornerback Bradley Roby (21) runs with the / Nathan Ray Seebeck-USA TODAY Sports
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Welcome to one of the best weekends of 2022!

Not only do we have the holidays to enjoy, but we have a full slate of NFL games to watch and bet on.

In this article, I'll give you my straight up moneyline pick for all 16 games set to take place in Week 16. If you're looking for picks against the spread, this isn't the article for all. All we care about here is what team is going to win the game.

If you want my best bet for each game including spreads and totals, check out this week's episode of the Bacon Bets Podcast.

But for now, here are my straight up picks for all 16 NFL Week 16 games.

NFL Week 16 Moneyline Bets

Jacksonville Jaguars vs. New York Jets

  • Pick: Jets -113

Buffalo Bills vs. Chicago Bears

  • Pick: Bills -385

Detroit Lions vs. Carolina Panthers

  • Pick: Panthers +130

I keep trying to fade the Lions and it hasn't worked for me yet, but this could be the week. The Lions can't keep winning with the league's worst defense, especially now that they face a Panthers defense that has one of the best secondary's in the NFL.

New Orleans Saints vs. Cleveland Browns

  • Pick: Saint +130

The weather is going to be insane in Cleveland on Saturday, which means anything can happen when these two teams face off. The Browns have struggled to stop the run all season, so if New Orleans pounds the rock against them in less than ideal conditions, then Cleveland could be in trouble.

Houston Texans vs. Tennessee Titans

  • Pick: Texans +185

Seattle Seahawks vs. Kansas City Chiefs

  • Pick: Chiefs -425

New York Giants vs. Minnesota Vikings

  • Pick: Giants +176

Cincinnati Bengals vs. New England Patriots

  • Pick: Patriots +147

It's time to sell high on the Bengals after their latest hot streak and buy low on the Patriots after their embarressing loss to the Raiders. New England still has one of the best defenses in the NFL, and it's time we give them the respect they deserve.

Atlanta Falcons vs. Baltimore Ravens

  • Pick: Ravens -320

Washington Commanders vs. San Francisco 49ers

  • Pick: 49ers -335

Philadelphia Eagles vs. Dallas Cowboys

  • Pick: Cowboys -210

Las Vegas Raiders vs. Pittsburgh Steelers

  • Pick: Raiders +126

Green Bay Packers vs. Miami Dolphins

  • Pick: Dolphins -196

Denver Broncos vs. Los Angeles Rams

  • Pick: Broncos -135

Tampa Bay Buccaneers vs. Arizona Cardinals

  • Pick: Buccaneers -330

Los Angeles Chargers vs. Indianapolis Colts

  • Pick: Colts +195

You can track Iain’s bets on Betstamp here.


Game odds refresh periodically and are subject to change.