NFL Week 1 Odds, Over/Under (Every Team's Spread, Moneyline, and Total)

Josh Allen and the Buffalo Bills are 2.5-point road favorites in Los Angeles to open the NFL season against the Super Bowl Champion L.A. Rams.
Josh Allen and the Buffalo Bills are 2.5-point road favorites in Los Angeles to open the NFL season against the Super Bowl Champion L.A. Rams. / Jamie Germano / USA TODAY NETWORK

We've finally made it to the start of the NFL regular season!

Week 1 offers several noteworthy matchups, beginning with the defending Super Bowl champion L.A. Rams as short home underdogs when they kick off against this year's Super Bowl-favorite Buffalo Bills.

In the early slate on Sunday, one notable matchup includes former Cleveland Browns quarterback Baker Mayfield facing his former team at home as his Carolina Panthers are short home favorites after opening as 3-point underdogs this offseason.

Later in the day, the highest total game on the board features the Kansas City Chiefs at the Arizona Cardinals, while the Los Angeles Chargers rematch against the Las Vegas Raiders in L.A. from last year's win-or-go-home Week 18 matchup that put the Raiders in the postseason.

Sunday Night Football features a Week 1 rematch between the Tampa Bay Buccaneers and Dallas Cowboys from a season ago, and Russell Wilson returns to Seattle in his first game with the Denver Broncos on Monday Night Football.

Lastly, here are all the NFL coaches making their regular season debuts with their new teams:

  • Dennis Allen - New Orleans Saints at Atlanta Falcons
  • Matt Eberflus - Chicago Bears vs. San Francisco 49ers
  • Lovie Smith - Houston Texans vs. Indianapolis Colts
  • Mike McDaniel - Miami Dolphins vs. New England Patriots
  • Doug Pederson - Jacksonville Jaguars at Washington Commanders
  • Josh McDaniels - Las Vegas Raiders at Los Angeles Chargers
  • Kevin O'Connell - Minnesota Vikings vs. Green Bay Packers
  • Brian Daboll - New York Giants at Tennessee Titans
  • Todd Bowles - Tampa Bay Buccaneers at Dallas Cowboys
  • Nathaniel Hackett - Denver Broncos at Seattle Seahawks

Now, let's get to the odds.

NFL Week 1 Odds for Every Team

Buffalo Bills vs. Los Angeles Rams Odds, Spread and Total

New Orleans Saints vs. Atlanta Falcons Odds, Spread and Total

Cleveland Browns vs. Carolina Panthers Odds, Spread and Total

San Francisco 49ers vs. Chicago Bears Odds, Spread and Total

Pittsburgh Steelers vs. Cincinnati Bengals Odds, Spread and Total

Philadelphia Eagles vs. Detroit Lions Odds, Spread and Total

Indianapolis Colts vs. Houston Texans Odds, Spread and Total

New England Patriots vs. Miami Dolphins Odds, Spread and Total

Baltimore Ravens vs. New York Jets Odds, Spread and Total

Jacksonville Jaguars vs. Washington Commanders Odds, Spread and Total

Kansas City Chiefs vs. Arizona Cardinals Odds, Spread and Total

Las Vegas Raiders vs. Los Angeles Chargers Odds, Spread and Total

Green Bay Packers vs. Minnesota Vikings Odds, Spread and Total

New York Giants vs. Tennessee Titans Odds, Spread and Total

Tampa Bay Buccaneers vs. Dallas Cowboys Odds, Spread and Total

Denver Broncos vs. Seattle Seahawks Odds, Spread and Total

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