NFL Week 5 Betting Trends for Every Team, Every Game (Steelers Reach Historical Feat as Huge Underdog vs. Bills)

Head Coach Mike Tomlin of the Pittsburgh Steelers is off to a 1-3 start this season, while also going 1-2-1 against the spread.
Head Coach Mike Tomlin of the Pittsburgh Steelers is off to a 1-3 start this season, while also going 1-2-1 against the spread. / Michael Longo/For USA Today Network /

It's amazing what stability can do for an NFL organization.

The Pittsburgh Steelers have had three NFL coaches going all the way back to the AFL/NFL merger in 1970: Chuck Noll (1969-1991), Bill Cowher (1992-2006), and Mike Tomlin (2007-current day).

As a result, they've gone 497-326 since 1969.

Yet even in down years, the Steelers were never as big of an underdog as they are this week when they head to Buffalo to face the Bills. If the line closes at 14, where it currently sits, it would be the first time since the merger that the Steelers have been two-touchdown underdogs in an NFL game.

Week 5 is chock-full of fascinating wagering trends that bettors can compile before making their selections this week. For example, you might have seen that Miami Dolphins backup quarterback Teddy Bridgewater has been one of the best bets in NFL history when it comes to covering the spread.

There's also Patrick Mahomes, who plays in his second straight primetime matchup on Monday Night Football vs. the Las Vegas Raiders. Over his career, Mahomes is 4-1-1 ATS on Monday Night Football, and 6-4 ATS in prime time against divisional opponents. In six career games vs. the Raiders, he's thrown for 22 touchdowns to just three interceptions.

Let's dive closer into every game's latest odds for Week 5 in the NFL, and take a look at several noteworthy betting trends for each team in their respective matchups:


Indianapolis Colts vs. Denver Broncos Betting Trends and Odds


  • Under is 9-0 in the Colts’ last nine games
  • Colts are 5-0 ATS in their last five games as road underdogs
  • The Colts are 1-3 ATS this season.
  • The UNDER is 4-0 in Indianapolis’ four games in 2022. 
  • Frank Reich is 13-7-2 ATS as a road underdog as the Colts’ head coach. 


  • Under is 6-2 in the Broncos’ last eight games as home favorites
  • The Broncos are 1-3 ATS this season.
  • The Broncos are 2-0 straight up at home this season. 
  • The UNDER is 3-1 in Denver’s four games in 2022.


New York Giants vs. Green Bay Packers Betting Trends and Odds


  • New York is 3-1 ATS 
  • New York is 2-0 outright as an underdog
  • New York games are 3-1 to the under
  • Under is 11-2 in Giants’ last 13 games as underdogs


  • Green Bay is 2-2 ATS 
  • Green Bay games are 3-1 to the under


Pittsburgh Steelers vs. Buffalo Bills Betting Trends and Odds


  • Pittsburgh’s games are 2-2 to the over
  • Pittsburgh is 1-2-1 ATS
  • Pittsburgh is 1-2 outright as an underdog 


  • Buffalo is 2-1-1 ATS 
  • Buffalo’s games are 3-1 to the under

Los Angeles Chargers vs. Cleveland Browns Betting Trends and Odds


  • The Chargers are 3-1 against the spread this season
  • The Chargers are 1-3 ATS as road favorites under Brandon Staley


  • The Browns are 2-2 ATS this season
  • Kevin Stefanski is 1-1 ATS as a home underdog
  • The OVER is 3-1 in Cleveland’s four games this season

Houston Texans vs. Jacksonville Jaguars Betting Trends and Odds


  • Texans are 8-0 straight up in last eight games vs. Jaguars
  • Texans are 2-10 straight up in last 12 road games
  • Texans are 4-1 ATS in last five games against Jaguars


  • Jaguars are 3-9 ATS in last 12 games
  • The UNDER is 5-1 in Jaguars last six home games
  • Jaguars are 1-9 ATS in their last 10 Week 5 games

Chicago Bears vs. Minnesota Vikings Betting Trends and Odds


  • Bears are 4-11-1 ATS in their last 16 games
  • Bears are 1-5 ATS in their last six road games
  • Bears are 0-6 ATS in their last six games against NFC North opponents


  • Vikings are 4-1 ATS in their last five games against the Bears
  • The OVER is 9-3 in the Vikings last 12 games

Detroit Lions vs. New England Patriots Betting Trends and Odds


  • The OVER is 6-0 in the Lions’ last six games
  • Lions are 0-5 straight up in last five road games


  • Patriots are 6-3 ATS in their last nine games against the Lions
  • Patriots are 2-6-1 ATS in their last nine games
  • The OVER is 7-0 in the Patriots last seven home games
  • Patriots are 6-1 ATS in their last seven Week 5 games

Seattle Seahawks vs. New Orleans Saints Betting Trends and Odds


  • The UNDER is 10-5 in the Seahawks’ last 15 road games
  • Seahawks are 5-3 ATS in their last nine games as underdogs
  • Seahawks are 5-1 ATS in their last six games played in October


  • The UNDER is 8-3 in the Saints last 11 games
  • Saints are 1-6 straight up in their last seven home games
  • Saints are 5-10 ATS in their last 15 games played in Week 5

Miami Dolphins vs. New York Jets Betting Trends and Odds


  • Miami 4-1 ATS in the last five games and 4-1 ATS vs. AFC
  • Miami 14-6-1 ATS since 2021 after a straight up loss
  • Unders are 9-3 in the last 12 games vs. AFC & AFC East
  • Dolphins 4-1-1 ATS in last nine games vs. New York


  • New York 5-1 ATS in last six home games vs. teams above .500
  • New York 2-7 ATS in last nine games after an ATS win, 1-6 ATS in last seven after a SU win
  • Over 5-1 in Jets last six games vs. above .500 teams

Atlanta Falcons vs. Tampa Bay Buccaneers Betting Trends and Odds


  • Falcons are 7-2-1 ATS in their last 10 road games
  • Falcons are 2-9 straight up in last 11 games against NFC South opponents
  • The OVER is 7-1 in the last eight meetings between the Falcons and Bucs


  • Buccaneers are 5-2 ATS in last seven games against Falcons
  • Buccaneers are 9-2 straight up in last 11 games against NFC South opponents
  • Buccaneers are 5-12 ATS in last 17 games played in October

Tennessee Titans vs. Washington Commanders Betting Trends and Odds


  • Tennessee still yet to cover as a favorite this year
  • The Titans are 2-2 against the over this season


  • Under is 10-1 in Commanders’ last 11 games as home underdogs
  • The Commanders are 0-3 ATS in their last three games
  • Washington has hit the under in two straight games


San Francisco 49ers vs. Carolina Panthers Betting Trends and Odds


  • In their last six games as at least 6-point favorite, the 49ers are 5-1 ATS
  • San Francisco is 11-6 SU as an away favorite since 2017


  • Carolina is 6-17 SU following a loss since 2020
  • The Panthers are 0-3 ATS in non-divisional games this season

Philadelphia Eagles vs. Arizona Cardinals Betting Trends and Odds


  • Philadelphia has covered in its last three games
  • The Eagles are 7-3-1 ATS as a favorite since the start of last year. 


  • The Cowboys are 4-0 SU with Cooper Rush as the starter
  • Dallas is 16-5 ATS since the start of last season

Dallas Cowboys vs. Los Angeles Rams Betting Trends and Odds


  • The Cowboys are 4-0 SU with Cooper Rush as the starter
  • Dallas is 16-5 ATS since the start of last season


  • The Rams are 4-5 ATS as road favorites since 2021
  • Los Angeles is 1-3 ATS this year


Cincinnati Bengals vs. Baltimore Ravens Betting Trends and Odds


  • The under is 4-0 in Bengals’ games this year
  • The Bengals have covered in their last two games


  • The Ravens are 2-0 ATS in their wins and 0-2 ATS in their losses
  • Baltimore and Cincinnati are 2-2 ATS and SU in their last four meetings


Las Vegas Raiders vs. Kansas City Chiefs Betting Trends and Odds


  • The Raiders are 1-3 against the spread this season
  • The OVER is 2-1-1 in Vegas’ four games this season


  • The Chiefs are 35-40-2 ATS as home favorites under Andy Reid
  • The Chiefs have won six straight primetime games
  • Kansas City is 2-2 against the spread this season

Game odds refresh periodically and are subject to change.