NFL Week 5 Schedule, Odds, Lines and Over/Unders (Every Team's Spread, Moneyline and Total)

"Cooper Rush, your table is ready."

After the Dallas Cowboys' odds to win the division went from first to worst following Dak Prescott's right thumb injury, America's team is starting to feel themselves over the last three weeks.

Rush has led the Cowboys to three straight wins, putting them at 3-1 in the early going of the 2022 season, and just a game back of the undefeated Philadelphia Eagles in the NFC East. With his start, Rush became the only Dallas quarterback to ever win his first four starts in a Cowboys uniform.

This week, he faces his most daunting task yet when the Cowboys travel to L.A. to face the defending Super Bowl champion Rams in the late afternoon game of the week on FOX.

As for the rest of the NFL Week 4 headlines, Patrick Mahomes and the Kansas City Chiefs curb-stomped the Tampa Bay Buccaneers 41-31 in prime time, the Eagles came back from 14-0 against former head coach Doug Pederson and the Jacksonville Jaguars to remain the league's lone undefeated team, and the Green Bay Packers avoided an overtime scare at home to Bailey Zappe and the New England Patriots, who entered their matchup as the biggest underdogs of the week.

Week 5 in the NFL kicks off Thursday night as the struggling Indianapolis Colts look for their second win of the season when they head to Denver to take on the Broncos. On Sunday Night Football, the Baltimore Ravens look for their first win at home after blowing two massive leads to the Buffalo Bills and Miami Dolphins when they host the Cincinnati Bengals.

Here's your first look at the opening odds for every NFL matchup in Week 5, along with the latest up-to-date spreads, moneylines and over/unders in real-time for each team.

Find more insights and betting plays for Week 5 on our NFL Expert Picks and Predictions page!