Oklahoma State vs. Iowa State Prediction, Odds, Spread and Over/Under for College Football Week 8

Oklahoma State looks to remain unbeaten when as 5.5 point underdogs against Iowa State.
Oklahoma State looks to remain unbeaten when as 5.5 point underdogs against Iowa State. / Scott Wachter-USA TODAY Sports

The Oklahoma State Cowboys are the No. 8 ranked team in the country, yet head into this game as near touchdown underdogs against unranked Iowa State.

The Cowboys are a perfect 6-0 and come off a strong victory over the Texas Longhorns 32-24 on the back of senior RB Jaylen Warren who ran for 193 yards, 

The Cyclones are 4-2 on the year and 2-1 in the Big 12, but are on a two-game winning streak after beating up on the Kansas State Wildcats 33-20. They're led by their own stud RB in Breece Hall who ran for 197 yards and 2 touchdowns in the win. 

Let’s break down some matchup stats and odds from WynnBET Sportsbook to make a pick on this game. 

Oklahoma State vs Iowa State Odds, Spread and Over/Under


  • Oklahoma State +6.5 (-110)
  • Iowa State -6.5 (-110)


  • Oklahoma State +220
  • Iowa State -260


  • 48.0 (-110)

Oklahoma State vs Iowa State Trends

  • Oklahoma State is 8-1 SU in their last 9 games against Iowa State.  
  • The OVER is 4-2 in the last 6 games between these two teams. 
  • Iowa State is 5-2 ATS in their last 7 games against Big 12 opponents.  

Oklahoma State vs Iowa State Pick

The Cowboys have remained undefeated all season but have also rewarded betters with a 4-2 ATS record. After failing to cover the first two weeks of the season, the Cowboys have a 4-0 streak of winning and covering. Two of those games had the Cowboys as underdogs and two as a favorite. The two games the Cowboys failed to cover featured spreads of -33.5 against Missouri State and -11.5 against Tulsa. 

Iowa State has struggled a bit in the win column along with covering spreads as a favorite this year. In three games as a single-digit favorite, the Cyclones covered just once, last week against Kansas state -6.5. 

It will be an interesting matchup between two teams who lean heavily on their running games. The Cowboys pass on only 35.14% of plays while the Cyclones are a bit closer to half and half with a 48.66% pass rate. The Cowboys rushing attack ranks 4th in rushes per game but 36th in rushing yards per game. While the Cyclones rush the ball much less, they have more success and rank 6th in the nation in yards per attempt. 

The teams rank similarly in terms of rushing defense as well. With each in the top-20 in rushing yards allowed per game. 

What I like about the Cowboys here is their ATS record playing as an underdog and, even more, their SU record in those same games. Once again the Cowboys enter a game as a single-digit underdog and I like their chances to emerge victorious yet again. They are 4-0 ATS in their last fur games on the road and 16-5 ATS vs teams with a winning record. 

I realize last week’s game vs Texas was scary. But OK State showed me something in that game. They dug themselves out of a hole and rallied to steal the comeback win from Texas. They also finished with nearly 400 yards on offense with an average of 4.9 yards per play. 

This should be a fun game all around but even more enjoyable if you can cash an underdog bet on an undefeated top-10 team. 

Prediction: Oklahoma State +220

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