Packers vs. Bills Prediction, Odds, Spread and Over/Under for NFL Week 8

Oct 23, 2022; Landover, Maryland, USA; Green Bay Packers quarterback Aaron Rodgers (12) passes the
Oct 23, 2022; Landover, Maryland, USA; Green Bay Packers quarterback Aaron Rodgers (12) passes the / Geoff Burke-USA TODAY Sports
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If you set the betting line for a game between the Green Bay Packers and Buffalo Bills before the season started, there's no way you would have set the Bills as double-digit favorites.

But yet, here we are. The Packers have lost three-straight games to the New York Giants, New York Jets, and the Washington Commanders. That's a terrible stretch of games, and now they have to take on the Super Bowl favorites in Buffalo.

Can Aaron Rodgers and the Packers even keep the game close? Let's take a look at the odds, trends, and my best bet.

Packers vs. Bills Odds, Spread, and Total

Packers vs. Bills Betting Trends

  • Packers are 1-5 ATS in their last six road games
  • Packers are 13-4 straight up in their last 17 games against AFC opponents
  • Bills are 8-2-2 ATS in their last 12 games
  • Bills are 10-1-1 in their last 12 games against NFC opponents
  • The UNDER is 5-1 in the Bills' last six games

Packers vs. Bills Prediction and Pick

The Packers were a bad team to bet on the past few weeks when they were around touchdown favorites. Now, they're double-digit underdogs. That is a wild shift in betting lines, and I think it's an overreaction to a bad run by the Packers.

Sure, the Packers aren't likely Super Bowl contenders, but they're not a "bad" teams. They rank 17th in yards per play and 12th in opponent yards per play. Those aren't great numbers by a long stretch, but they aren't bad.

The Packers defense does have some bright spots as well, including being ranked third in opponent third down conversion rate, sixth in opponent red zone touchdown scoring percentage, and ninth in sack percentage.

The Bills are clearly better, but if I'm going to lay over 10 points on a team, I'm going to need that squad to be playing against one of the worst teams in the NFL, which the Packers certainly aren't.

You can track Iain's bets on Betstamp here.


Game odds refresh periodically and are subject to change.