Panthers vs. Bills Prediction, Odds, Against Spread and Over/Under for NFL Week 15

The Carolina Panthers are struggling to find a quarterback while the Bills are struggling to do just about anything.
The Carolina Panthers are struggling to find a quarterback while the Bills are struggling to do just about anything. / Jim Dedmon-USA TODAY Sports

The Cam Newton experiment has thus far been a failure for the Carolina Panthers as he has yet to win a single start since returning. The Panthers dropped to 5-8 after getting beat by the Atlanta Falcons 29-21. The loss dropped them to the basement of the NFC South and was the latest disappointment for this team.

This could be good news for the Buffalo Bills, who are teetering on missing out on the playoffs entirely. After being favorites to win the Super Bowl a few weeks ago, things started to go south when they lost to the Jaguars. Since then, the Bills have gone 2-3 and have lost their first place spot in the AFC East. If things don’t turn around fast, the Bills could be one of the biggest disappointments of the 2021 season. Here are the odds for this Week 15 matchup, courtesy of WynnBET Sportsbook.

Panthers vs. Bills, Spread, and Total Odds


  • Panthers -10.5 (-110)
  • Bills +10.5 (-110)


  • Panthers +425
  • Bills -550


  • 43.5 (Over -110/Under -110)

Panthers vs. Bills Betting Trends

  • The Panthers are 5-8 against the spread (ATS) in their last 13 games. 
  • The Panthers are 3-3 ATS in their last six games on the road. 
  • The Panthers are 2-1 ATS as a road underdog this season. 
  • The Panthers are 2-2 ATS in non-conference games this season. 
  • The Bills are 7-6 ATS in their last 13 games. 
  • The Bills are 4-5 ATS in their last nine non-division games. 

Panthers vs. Bills Prediction and Pick

The Bills suffered a tough loss to Tom Brady and the Tampa Bay Buccaneers on Sunday, falling 33-27 in overtime. However, the Bills came alive in the second half after almost getting blown out of the arena. The Bills outscored Tampa Bay 24-3 in the final 60 minutes of play and showed some grit to get back into this game. Unfortunately for them, Brady did what he does and won the game on a 58-yard pass in extra time.

There is no denying that the Bills are very talented and If they expect to make a playoff run, they have to start playing like it this weekend. Losing the Bucs or Patriots is one thing, but the Bills have to start beating teams that are worse than them. While I think to do manage a win here, the 10.5 spread is just too vast for a team as inconsistent as the Bills. I think Newton keeps this game close enough to cover when all is said and done. 

Pick: Carolina Panthers +10.5 (-110)