Panthers vs. Cowboys: Odds, Spread, Over/Under and Prediction for NFL Week 4

Sep 19, 2021; Charlotte, North Carolina, USA; Carolina Panthers quarterback Sam Darnold (14) throws
Sep 19, 2021; Charlotte, North Carolina, USA; Carolina Panthers quarterback Sam Darnold (14) throws / Jim Dedmon-USA TODAY Sports

The Dallas Cowboys scored a blowout win over their rival Philadelphia Eagles on Monday Night Football, pushing them to the top of the NFC standings. 

In Week 4, they welcome the 3-0 Carolina Panthers, who will likely be without Christian McCafrey for at least a few weeks. 

Who has the edge in this one? Let’s get to the odds and preview for a battle of playoff hopefuls in the NFC, courtesy of WynnBET Sportsbook.

Panthers vs. Cowboys Spread, Odds and Total


Panthers: +5 (-110)

Cowboys: -5 (-110)


Panthers: +180

Cowboys: -220

Total: 50.5 (Over -110/Under -110)

Cowboys vs. Panthers Prediction and Pick

I do lean with the Panthers despite the injury to McCaffrey, but I really like the total in this one. I have this one pegged for 53 points despite the loss of the star running back, mainly due to the the game script. 

We’ll start on the Carolina side, where offensive coordinator Joe Brady has 10 days to draw up a scheme against a soft Dallas defense.

Yes, we just saw the Cowboys shut down the Philadelphia offense on MNF, but I expect Brady to come up with a sound game plan to get the ball out of Sam Darnold’s hands quickly and into his dynamic receivers hands. In the first two games of the season, Dallas was 28th in explosive pass defense, I think Brady can call a game that exposes the Cowboys secondary.

On the other side, we now have three weeks of data to show that Dak Prescott is fine after his season ending injury last season. We have also seen that Cowboys OC Kellen Moore is going to pass the ball at will with all the weapons Prescott has. While Michael Gallup has been sidelined and Amari Cooper is battling a rib injury, the likes of Cedrick Wilson and Tony Pollard have emerged in the passing game for Prescott.

The Panthers defense is one of my favorite units in the league, but they may be getting a bit too much credit in the market at this point given that they have faced two of the worst offenses in the league in the New York Jets and Houston Texans as well as a mediocre one in the New Orleans Saints. 

The Dallas offense is elite, and the Panthers will be without stud rookie corner Jaycee Horn either, so I'm expecting both passing games to be in control from the opening kick.

I lean with the Panthers staying close to the Cowboys at the current spread of 5, but I really like the over up to 51.5. 

Pick: Over 50.5, Lean Panthers +5

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