Patriots vs. Bills Prediction, Odds, Against Spread and Over/Under for NFL Week 13

The Patriots and Bills will battle it out for the top spot in the AFC in Week 13 NFL action.
The Patriots and Bills will battle it out for the top spot in the AFC in Week 13 NFL action. / David Butler II-USA TODAY Sports

Not many people believed that the AFC East would be a close battle at this point of the NFL season, but here we are.

The New England Patriots and Buffalo Bills will battle it out on Monday Night Football in Week 13, and the winner will be sitting atop the division. The Patriots currently hold the top spot at 8-4, but the Bills (7-4) can surpass them with a win.

This will be the first meeting between these two teams this season, and they'll have the rematch in Week 16 at Foxboro.

Here are the odds via WynnBET for this Week 13 Monday Night Football showdown.

Patriots vs. Bills Odds, Spread, and Total


  • Patriots +3 (-105)
  • Bills -3 (-115)


  • Patriots +140
  • Bills -160


  • 44 (Over -110/Under -110)

Patriots vs. Bills Betting Trends

  • Patriots are 6-0 ATS in their last six games.
  • The OVER is 6-2 in the Patriots last eight games.
  • The Patriots are 6-3 ATS in last nine games vs. Bills.
  • Bills are 13-6-1 ATS in their last 20 games.
  • The Bills are 1-8 SU in their last 9 home games against the Patriots.

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Patriots vs. Bills Prediction and Pick

The Patriots have been the hottest team in the NFL recently, winning and covering the spread in their last six games, but it's time to sell them while their stock is high.

If you're able to look past the few dud games that the Bills have played this season, they're still arguably the best team in the NFL from a statistics point of view. They rank sixth in the NFL in yards per play (5.9), and first in opponent yards per play (4.6). The Patriots rank 14th and third in those respective stats.

If there is one weakness that the Bills do have, it's in stopping the run. Elite running backs like Derrick Henry and Jonathan Taylor have had big games against Buffalo, but New England doesn't have a workhorse back that's at the level of those two players.

Don't let recency bias over the Patriots cloud your judgement. Buffalo is the play in this spot.

Pick: Bills -3