Purdue vs. Syracuse Prediction, Odds, Spread and Over/Under for College Football Week 3

Syracuse and Purdue meet in Western New York on Saturday afternoon in an intriguing non conference team.

Both the Orange and Boilermakers are looking to take the next step as a program and bring intriguing offensive talent to the game. The Orange have a dynamic offense headlined by running back Sean Tucker and Garrett Shrader while Purdue is a pass-heavy offense that relies on the arm of quarterback Aidan O'Connell.

This game is a projected toss up, so let's look for some betting value by first checking out the odds from FanDuel Sportsbook:

Purdue vs. Syracuse Odds, Spread and Total

Purdue vs. Syracuse Betting Trends

• Syracuse is 17-12-1 against the spread (ATS) as a home underdog over the last 10 seasons
• In games with a line between -3 and +3 under Jeff Brohm, Purdue is 2-2 ATS on the road
• Purdue is 8-4 ATS in non conference play under Brohm

Purdue vs. Syracuse Prediction and Pick

This game opened with Purdue as a road favorite, but has quickly moved to a pick 'em. Still, I think there's still room to go on the Syracuse side. I make the Orange -2 in this non conference matchup.

The Orange have seen tremendous returns early on under first year offensive coordinator Robert Anae, who comes from Virginia. With the Cavaliers, Anae helped build a top five offense that averaged nearly seven yards per play and was 10th in success rate in 2021, and he has helped the Orange take a leap on that side of the ball.

Shrader looks much more comfortable under center, the team is averaging 4.24 points per drive, which is good for top 10 in the country. Meanwhile, Tucker picked up on his near-1,500 yard campaign in 2021 with 313 total yards thus far with three touchdowns.

They'll face a Purdue team that allowed 35 points to Penn State at home, is still transitioning from losing defensive coordinator Pete Lambert to Wake Forest and is heavily reliant on the passing game.

While it's a small sample, the Orange were able to give dual threat Louisville quarterback Malik Cunningham fits and have generated 15 tackles for loss through two games (this could be possibly inflated due to the UConn victory).

Based on one data point against quality competition, Purdue couldn't hold down a Penn State offense that I find good but not great, while Syracuse held down a possibly explosive quarterback in Cunningham while scoring 31 points in the process.

I'm going to trust Anae to scheme up a strong game plan and get the Orange to the window and start 3-0.