Rams vs. 49ers Prediction, Odds, Spread and Over/Under for NFL Week 10

Both the LA Rams and SF 49ers are looking for bounce-back performances when the two meet on Monday night of Week 10.
Both the LA Rams and SF 49ers are looking for bounce-back performances when the two meet on Monday night of Week 10. / Kirby Lee-USA TODAY Sports

We have a very important NFC West matchup to look forward to in primetime of Week 10.

Monday Night Football this week features the Los Angeles Rams on the road against the San Francisco 49ers at Levi’s Stadium. Both teams come off Week 9 losses as home favorites and need wins this week to keep pace with the rest of the division. 

The Rams are in a much better spot overall. With a 7-2 record, they fell out of the top spot in the NFC West after the Cardinals won. They will need to do a lot better than last week if they have a chance at the playoffs. Despite ranking third in the league in passing, the Rams scored just one TD off a three-yard reception to Sony Michel. The Rams did outgain the Titans 347-194 but were let down by several ill-timed turnovers, with one being taken to the house. 

While the Rams struggle to keep up with the Cardinals, the 49ers are just struggling to stay afloat. The 49ers have lost five of their last six games and look nothing like the team that went to the Super Bowl in 2020. The 49ers took a big 'L' last week against a Cardinals team without Kyler Murray or DeAndre Hopkins. 

Which of these two teams has a better shot at bouncing back in Week 10? Here are the odds for this Week 10 matchup between NFC West rivals, courtesy of WynnBET Sportsbook.

Rams vs. 49ers, Spread, and Total Odds


  • Rams: -4.0 (-110)
  • 49ers: +4.0 (-110)


  • Rams: -145
  • 49ers: +125


  • 52.0 (Over -110/Under -110)

Rams vs. 49ers Betting Trends

  • The Rams are 2-4 against the spread (ATS) in their last six games. 
  • The Rams are 3-8 ATS in their last 11 games against the 49ers.
  • The UNDER is 6-2 in the last eight-game between these two teams at Levi’s Stadium. 
  • The 49ers are 1-5 ATS in their last six games. 
  • The 49ers are 0-8 straight-up (SU) in their last eight games at home. 
  • The 49ers are 1-4 ATS in their last five games against the NFC. 

Rams vs. 49ers Prediction and Pick

The 49ers make it very hard to bet on them. Their defense was downright terrible against a Cardinals team without several of their best offensive players. It was a perfect game for the Niners to step up and prove their detractors wrong, but only managed to make it worse. The 49ers were also unable to get anything going on the ground despite a strong day from Jimmy G. The loss dropped San Fran to 0-4 at home. 

I’ll admit, the Rams didn’t look like a 7-2 team on Sunday night against the Titans. It was an ugly game that the team will want to put behind them. But, the Rams are still a far superior team. The offense is one of the most explosive in the NFL and the 49ers don’t have what it takes to defend them. Especially in the secondary where Cooper Kupp and Robert Woods should feast. SF is the 25th ranked scoring defense and will be in for another tough game at home.

Pick: Los Angeles Rams -4.0 (-110)

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