Saints vs. Titans Prediction, Odds, Spread and Over/Under for NFL Week 10

The New Orleans Saints are looking for their first win after losing their starting QB. Can they upset the Titans on the road in Week 10?
The New Orleans Saints are looking for their first win after losing their starting QB. Can they upset the Titans on the road in Week 10? / Chuck Cook-USA TODAY Sports

After one game without their starting quarterback Jameis Winston it is clear the New Orleans Saints are in trouble The 3-4 Atlanta Falcons extended their winning streak in an upset win over the Saints in Week 9. This is a game New Orleans will want to put behind them as they head to Nissan Stadium to take on the Titans. 

The Tennessee Titans will also be without their best offensive player with Derrick Henry but it didn’t seem to slow them down last week against the Rams.

Tennessee, as seven-point underdogs, marched into this game and dominated the Rams, winning 28-16. The win can be credited mostly to the Titans' defense that managed to stifle a strong Rams’ offense led by Matthew Stafford. The Rams ended the day minus one in the turnover battle and 4-15 on third down.

It will be interesting to see how each team has adjusted their game plan two weeks removed from losing their offensive leads. 

Here are the odds for this Week 10 matchup, courtesy of WynnBET Sportsbook.

Saints vs. Titans, Spread, and Total Odds


  • Saints: +3.0 (-110)
  • Titans: -3.0 (-110)


  • Saints: +140
  • Titans: -160


  • 45.0 (Over -110/Under -110)

Saints vs. Titans Betting Trends

  • The OVER is 4-1 in the Saints’ last five games. 
  • The Saints are 2-5 straight-up (SU) in their last seven games against the Titans. 
  • The UNDER is 4-1 in the Saints’ last five games on the road against the Titans. 
  •  The Titans are 5-0 against the spread (ATS) in their last five games. 
  • The Titans are 7-2 ATS this season. 

Saints vs. Titans Prediction and Pick

Despite the impressive win over the Rams, the Titans' offense can’t take a whole lot of credit. In their first game without Derrick Henry, the team combined to average 3.5 yards per play with less than 300 yards in the game. 

The big difference between the loss of Henry and Winston is that Winston is the best weapon the Saints have on offense. Henry might be the best weapon in the NFL. Coincidentally, the running back also missed the last game between these two games in 2019 with a hamstring injury. 

These factors make this game trickier than most to handicap. In this case, I generally turn to the coaching. In this instance, I have to give the edge to Sean Payton and the Saints. Payton has shown time and time again that he can game plan around unforeseen issues. Given an extra week of work with the first team, Trevor Siemian and Payton can find a way to beat the Titans on their home turf. 

Pick: Saints +140 to win

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