Seahawks vs. Cardinals Prediction, Odds, Against Spread and Over/Under for NFL Week 18

The Cardinald and Seahawks will face-off in an NFC West battle in Week 18 of the NFL.
The Cardinald and Seahawks will face-off in an NFC West battle in Week 18 of the NFL. / Steven Bisig-USA TODAY Sports

The Arizona Cardinals have already clinched their spot in the 2021 NFL postseason, but they have a chance to improve their seeding with a win over the Seattle Seahawks in the final week of the regular season.

Meanwhile, the Seahawks have nothing left to play for except pride and it may be the final time we'll see Pete Carrol and Russell Wilson teamed up together.

Let's take a look at the odds for the game, courtesy of WynnBET.

Seahawks vs. Cardinals Odds, Spread, and Total


  • Seahawks +6.5 (+100)
  • Cardinals -6.5 (-120)


  • Seahawks +230
  • Cardinals -290


  • 48 (Over -110/Under -110)

Seahawks vs. Cardinals Betting Trends

  • The OVER is 4-1 in the Seahawk's last five games.
  • Seahawks are 2-5 ATS in their last seven games vs. NFC West opponents.
  • Cardinals are 6-2 ATS in their last eight games vs. Seahawks.
  • Cardinals are 1-4 ATS in their last five games.
  • Cardinals are 4-1 ATS against NFC West opponents this season.

Seahawks vs. Cardinals Prediction and Pick

The difference maker in this game is going to be the secondary of the two teams. The Cardinals rank inside the top 10 in passing defense, while the Seahawks rank in the bottom 10. To be specific, Seattle is 25th in opponent yards per pass attempt, giving up 7 yards per throw. That's not a good sign when you're facing one of the most electric passers in the NFL in Kyler Murray.

The Seahawks, offensively, have look good at times this season, but their third down issues have plagued them all year. They're 27th in the league in third down conversion rating, getting a first down on just 35.36% of tries. That's a stark contrast to the Cardinals, who rank 5th in that stat, converting on 44.83% of third downs.

I'm going to try not to overthink this one, and back the playoff team in Arizona.

Pick: Cardinals -6.5