Syracuse vs. Louisville Prediction, Odds, Spread and Over/Under for College Football Week 11

The Syracuse Orange have now won back-to-back games, defeating Boston College in Week 10, 21-6. Syracuse has played very competitive football this season, with all four of its losses this season within 10 points.

After losing to Clemson in Week 10, Louisville has now lost four of their last five games. Quarterback Malik Cunningham is dealing with an ankle issue and is questionable for Saturday’s matchup with Syracuse.

Here are the odds for this ACC matchup, courtesy of WynnBET Sportsbook.

Syracuse vs. Louisville Odds, Spread and Over/Under

Spread:

• Syracuse +3 (-110)
• Louisville -3 (-110)

Moneyline:

• Syracuse +130
• Louisville -150

Total:

• 55 (Over -110/Under -110)

Syracuse vs. Louisville Betting Trends

• Syracuse is 8-1 against the spread this season.
• Louisville is 4-5 against the spread this season.
• The Orange are 5-0 against the spread in their last five games as an underdog.
• The Under is 4-0 in the Cardinals last four home games as a favorite.
• The favorite is 7-0 against the spread in the last seven meetings.

Syracuse vs. Louisville Prediction and Pick

If you haven’t heard of Syracuse running back Sean Tucker, that’s a shame. If I were to hand out my own personal Heisman Trophy, I would give it to him. 

Tucker ran for 207 yards and a touchdown last week against Boston College and he should be able to produce another strong outing on the ground against Louisville in Week 11. Tucker has run for 1,267 yards, behind only Kenneth Walker III of Michigan State, and has scored 11 touchdowns. 

Louisville’s defense lost star linebacker Monty Montgomery to an torn ACL in the win over UCF on Sept. 17, and it has been for their defense since. An already suspect defense losing it’s star is a recipe for disaster. If Malik Cunningham doesn’t suit up this week either, the Orange will pick up the win.

Sean Tucker should roll over this Cardinals defense. 

Pick: Syracuse +3 | Syracuse +130 ML