Top NFL Picks and Predictions Today (Even with Two Great Defenses, Back Points for Bills-Chiefs)
As Sunday's slate of games in Week 6 of the NFL approaches, perhaps two of the games of the year take place in the late window of matchups, as well as on Sunday Night Football.
The Buffalo Bills and Kansas City Chiefs square off from Arrowhead Stadium in Kansas City at 4:25 p.m. ET with the two highest favorites to win the AFC matching up against each other. If you're expecting Patrick Mahomes to remain undefeated as an underdog vs. the spread this afternoon, you may want to consider getting on board with Kansas City now before the lines move postgame.
Meanwhile, the Sunday Night Football matchup features the best team in the NFC against perhaps the biggest surprise of the season in the Dallas Cowboys vs. Philadelphia Eagles. Since Cooper Rush took over for Dak Prescott after being injured in Week 1, the Cowboys haven't lost; remaining just one game back of the undefeated Eagles in the division and could overtake them with a win on the road tonight.
Don't forget about the other 12 games on the slate for today and tomorrow!
Our team at BetSided has picks, props, and anytime touchdown bets for nearly every game over on our NFL expert picks page, but let's take our favorites for Week 6 and collect them all in one place here.
New England Patriots vs. Cleveland Browns Odds, Prediction and Pick
New England Patriots running back Rhamondre Stevenson is the top dog with Damien Harris out with a hamstring injury. Last week vs. the Detroit Lions, he cruised; rushing for 161 yards on 25 carries.
While Stevenson didn’t score a touchdown I expect he will in Week 6 vs. a Cleveland Browns team that has been terrible against the run. The Browns allow the third most yards per carry (5.3) this season as well as the third most rushing touchdowns (eight) through the first five games this year.
The Patriots are likely to lean on the running game, and Stevenson is clearly the team’s best option in the red zone. He also has 13 catches on the season, so he could find his way for six on a pass as well. – Peter Dewey
Find Peter Dewey’s full betting record here.
Arizona Cardinals vs. Seattle Seahawks Odds, Prediction and Pick
Arizona has been the worst scoring team in the first quarter this year, scoring literally zero points with a minus-38 point differential.
The Seahawks, however, are the second-best first quarter scoring team in the NFL, averaging 8.2 points per game in the first quarter, and 11.3 points over their last three.
Seattle's defense is not a worldbeater, but until Arizona shows that they can start scoring in the first quarter regardless of competition, I’ll gladly back Seattle early at home. – Ben Heisler
Follow all of Ben's betting plays in real-time HERE!
Buffalo Bills vs. Kansas City Chiefs Odds, Prediction and Pick
The Chiefs are the highest-scoring team in the league and the Bills are the second-highest. Buffalo is the best 3rd down team in the league and the Chiefs rank right below them. Both of these offenses can score at will, regardless of what their defensive stats indicate.
One of the key questions is how the Chiefs will face against the Bills' pass rush. I think they will be just fine. Buffalo is fairly banged up right now, and Mahomes should be able to take advantage.
Also, the Chiefs put up 41 points on the Tampa Bay Buccaneers the last time Patrick Mahomes was listed as an underdog. If he's is on his game, points will be scored. - Donnavan Smoot
You can find Donnavan Smoot’s full betting record here.
Dallas Cowboys vs. Philadelphia Eagles Odds, Prediction and Pick
CeeDee Lamb has not become the emerging star most of us had expected without Dak Prescott throwing him the ball.
His targets have dropped over the past two weeks, and he has only seen eight passes thrown his way in each of the last two games. Is that number really going to explode against a very good Eagles' defense in a divisional game in Philadelphia? I don't think so.
Against this Eagles secondary, I'm going to bet the UNDER on that number. - Iain MacMillan
You can track Iain's bets on Betstamp here.
Game odds refresh periodically and are subject to change.