USC vs. Stanford Prediction, Odds, Spread and Over/Under for College Football Week 2

Now for the real test.

USC won its first game against lowly Rice, 66-14, as Caleb Williams led the Trojans offense to explosive marks, but now comes a road trip to Stanford, who looks to get back on track with potential NFL quarterback prospect Tanner McKee. Can Lincoln Riley and the transfer-heavy Trojans show they are as good as advertised on the road?

Here are the odds for this early season PAC-12 showdown:

USC vs. Stanford Odds, Spread and Total

USC vs. Stanford Betting Trends

• Stanford is 2-6 against the spread (ATS) as a home underdog since 2019
• Since 2012, USC is 16-16 ATS as a road favorite

USC vs. Stanford Prediction and Pick

Stanford has taken money in this game, moving from 10.5 in the lookahead market down inside the key number of 10 at +9.5 as of this writing.

I'm not particularly high on either team this season, but for different reasons. I still think Stanford is at the bottom of the PAC-12 while I think USC is a step below conference champion material. I'm not rushing to lay the points with the Trojans, but I have little interest in taking the Tree given they are lacking the defensive pieces to keep up with the weapons USC has to offer.

Williams was electric against Rice, similar to how he was for Oklahoma last season with Riley. He completed 19-of-22 passes for 249 yards and two touchdowns will also rushing six times for 68 yards. I expect Jordan Addison to figure into the passing game on Saturday. He showed his touchdown scoring ability, hauling in both of Williams' passing touchdowns, but had only six targets.

This game is setting up for a track meet as the unproven USC defense needs to hold down a Stanford team that should take a step forward on the offensive end, I just don't trust them to keep up.

This is over or nothing for me, if this keeps trickling down I will be interested in the Trojans at the key number of -7.