Vikings vs. 49ers Updated Odds and Prediction: What Bettors Need to Know

Kirk Cousins face the 49ers in Week 12.
Kirk Cousins face the 49ers in Week 12. / Kelley L Cox-USA TODAY Sports

The Minnesota Vikings are looking to continue their push for a playoff spot in the NFC when they take on another playoff hopeful in the San Francisco 49ers

The 49ers are favored at home, and here are the latest odds via WynnBET for this Week 12 matchup: 

Vikings vs. 49ers Odds, Spread and Total


  • Vikings +3.0 (+100)
  • 49ers -3.0 (-120)


  • Vikings: +150
  • 49ers: -170


  • 49.0 (Over -110/Under -110)

49ers vs. Vikings Betting Trends

  • The Vikings are 6-4 against the spread this season.
  • The 49ers are 4-6 against the spread this season.
  • The Vikings are 4-1 ATS in their last five games.
  • The OVER is 6-1 in the Vikings last seven road games.
  • The UNDER is 7-1 in the last eight meetings between these teams.
  • The 49ers are 1-8 SU in their last nine home games.
  • The OVER is 5-0 in the 49ers last five games against NFC North opponents.

Vikings vs. 49ers Prediction and Pick

The Vikings are coming off of two big wins over the past two games, but BetSided’s Iain MacMillan thinks the 49ers are the team to back in this spot. 

“People began discounting the 49ers after a slow start to their season, but even at 5-5, their statistics show that they're a better football team than their record indicates. They rank seventh in the NFL in yards per play and sixth in opponent yards per play.

“Meanwhile, the Vikings have been solid on offense, ranking 13th in yards per play, but their defense leaves a lot to be desired. They rank 26th in opponent yards per play, 31st in opponent yards per carry, and 24th in opponent yards per pass attempt.

“Their biggest strength on defense is their pass rush. They have the third highest sack percentage at 8.07%, but with the 49ers relying heavily on the run game, we'll see how much of a factor it will play in this game.

“I expect the 49ers to slice through this Vikings defense with their run game, and I'm willing to lay the points with them at home.” 

Pick: 49ers -3.0 (-110)

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